Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

New interpretation of arterial stiffening due to cigarette smoking using a structurally motivated constitutive model

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Day-to-Day Reliability of Nonlinear Methods to Assess Walking Dynamics

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Cellular homeostatic tension and force transmission measured in human engineered tendon

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Assessment of intersegmental coordination of rats during walking at different speeds - Application of continuous relative phase

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Day-to-day reliability of gait characteristics in rats

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Commentary on Drug-Eluting Technologies

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Palliative Prostate Artery Embolization for Prostate Cancer: A Case Series

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Cutdown Technique is Superior to Fascial Closure for Femoral Artery Access after Elective Endovascular Aortic Repair

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Endovascular aortic repair reduces gluteal oxygenation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Prostate Artery Embolization for Lower Urinary Tract Symptoms in Men Unfit for Surgery

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Majken Enevoldsen
  • K-A Henneberg
  • J A Jensen
  • L Lönn
  • J D Humphrey
Vis graf over relationer
Cigarette smoking is the leading self-inflicted risk factor for cardiovascular diseases; it causes arterial stiffening with serious sequelea including atherosclerosis and abdominal aortic aneurysms. This work presents a new interpretation of arterial stiffening caused by smoking based on data published for rat pulmonary arteries. A structurally motivated "four fiber family" constitutive relation was used to fit the available biaxial data and associated best-fit values of material parameters were estimated using multivariate nonlinear regression. Results suggested that arterial stiffening caused by smoking was reflected by consistent increase in an elastin-associated parameter and moreover by marked increase in the collagen-associated parameters. That is, we suggest that arterial stiffening due to cigarette smoking appears to be isotropic, which may allow simpler phenomenological models to capture these effects using a single stiffening parameter similar to the approach in isotropic continuum damage mechanics. There is a pressing need, however, for more detailed histological information coupled with more complete biaxial mechanical data for a broader range of systemic arteries.
OriginalsprogEngelsk
TidsskriftJournal of Biomechanics
Vol/bind44
Udgave nummer6
Sider (fra-til)1209-11
Antal sider3
ISSN0021-9290
DOI
StatusUdgivet - 2011

ID: 33198162