New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary

Tomas Schmauck-Medina, Adrian Molière, Sofie Lautrup, Jianying Zhang, Stefan Chlopicki, Helena Borland Madsen, Shuqin Cao, Casper Soendenbroe, Els Mansell, Mark Bitsch Vestergaard, Zhiquan Li, Yosef Shiloh, Patricia L Opresko, Jean-Marc Egly, Thomas Kirkwood, Eric Verdin, Vilhelm A Bohr, Lynne S Cox, Tinna Stevnsner, Lene Juel RasmussenEvandro F Fang

Abstrakt

Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and pushing forward research on the biology of ageing. In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation, among other emerging ones. Amalgamation of the 'old' and 'new' hallmarks of ageing may provide a more comprehensive explanation of ageing and age-related diseases, shedding light on interventional and therapeutic studies to achieve healthy, happy, and productive lives in the elderly.

OriginalsprogEngelsk
TidsskriftAging
Vol/bind14
Udgave nummer16
Sider (fra-til)6829-6839
Antal sider11
ISSN1945-4589
DOI
StatusUdgivet - 29 aug. 2022

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