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Region Hovedstaden - en del af Københavns Universitetshospital
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New drug candidates for depression - a nationwide population-based study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. The Validity of Child and Adolescent Depression Diagnoses in the Danish Psychiatric Central Research Register

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  2. Reducing the rate of psychiatric Re-ADMISsions in Bipolar Disorder using smartphones The RADMIS trial

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  3. Familial risk and heritability of depression by age at first diagnosis in Danish twins

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  4. Hippocampal Volume and Memory Impairment after Electroconvulsive Therapy in Patients with Depression

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. High suicide rates during psychiatric inpatient stay and shortly after discharge

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. A nation-wide population-based longitudinal study mapping physical diseases in patients with bipolar disorder and their siblings

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. A skewed perspective - A reply to Kovvuru et al

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  3. Hippocampal subfield morphology in monozygotic twins discordant for affective disorders

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVE: To investigate whether continued use of non-aspirin NSAID, low-dose aspirin, high-dose aspirin, statins, allopurinol and angiotensin agents decreases the rate of incident depression using Danish nationwide population-based registers.

METHODS: All persons in Denmark who purchased the exposure medications of interest between 1995 and 2015 and a random sample of 30% of the Danish population was included in the study. Two different outcome measures were included, (i) a diagnosis of depressive disorder at a psychiatric hospital as in-patient or out-patient and (ii) a combined measure of a diagnosis of depression or use of antidepressants.

RESULTS: A total of 1 576 253 subjects were exposed to one of the six drugs of interest during the exposure period from 2005 to 2015. Continued use of low-dose aspirin, statins, allopurinol and angiotensin agents was associated with a decreased rate of incident depression according to both outcome measures. Continued uses of non-aspirin NSAIDs as well as high-dose aspirin were associated with an increased rate of incident depression.

CONCLUSION: The findings support the potential of agents acting on inflammation and the stress response system in depression as well as the potential of population-based registers to systematically identify drugs with repurposing potential.

OriginalsprogEngelsk
TidsskriftActa Psychiatrica Scandinavica
Vol/bind139
Udgave nummer1
Sider (fra-til)68-77
Antal sider10
ISSN0001-690X
DOI
StatusUdgivet - jan. 2019

ID: 56121007