Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

New drug candidates for depression - a nationwide population-based study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Trajectory of cognitive functions in bipolar disorder: for better or worse?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Incidence of suicidal behaviour and violent crime following antidepressant medication: a Danish cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Response to comment on Osler et al: misinterpretation of pre- and post differences invalidate the authors' conclusion

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  4. Societal costs of Borderline Personality Disorders: a matched-controlled nationwide study of patients and spouses

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Meta-analysis of antidepressant effects of anti-inflammatory drugs-reply

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  1. Automatically generated smartphone data and subjective stress in healthy individuals - a pilot study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Association between Mental Disorders and Subsequent Medical Conditions

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Forecasting Mood in Bipolar Disorder From Smartphone Self-assessments: Hierarchical Bayesian Approach

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Depression under graviditet: et klinisk dilemma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Hypomania/Mania by DSM-5 definition based on daily smartphone-based patient-reported assessments

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVE: To investigate whether continued use of non-aspirin NSAID, low-dose aspirin, high-dose aspirin, statins, allopurinol and angiotensin agents decreases the rate of incident depression using Danish nationwide population-based registers.

METHODS: All persons in Denmark who purchased the exposure medications of interest between 1995 and 2015 and a random sample of 30% of the Danish population was included in the study. Two different outcome measures were included, (i) a diagnosis of depressive disorder at a psychiatric hospital as in-patient or out-patient and (ii) a combined measure of a diagnosis of depression or use of antidepressants.

RESULTS: A total of 1 576 253 subjects were exposed to one of the six drugs of interest during the exposure period from 2005 to 2015. Continued use of low-dose aspirin, statins, allopurinol and angiotensin agents was associated with a decreased rate of incident depression according to both outcome measures. Continued uses of non-aspirin NSAIDs as well as high-dose aspirin were associated with an increased rate of incident depression.

CONCLUSION: The findings support the potential of agents acting on inflammation and the stress response system in depression as well as the potential of population-based registers to systematically identify drugs with repurposing potential.

OriginalsprogEngelsk
TidsskriftActa Psychiatrica Scandinavica
Vol/bind139
Udgave nummer1
Sider (fra-til)68-77
Antal sider10
ISSN0001-690X
DOI
StatusUdgivet - jan. 2019

ID: 56121007