Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

New drug candidates for depression - a nationwide population-based study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. The association between depressive mood and ischemic heart disease: a twin study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Lithium as the drug of choice for maintenance treatment in bipolar disorder

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Genome-wide gene expression in a pharmacological hormonal transition model and its relation to depressive symptoms

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Alcohol and delirium tremens: effects of average number of drinks per day and beverage type

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Parental alcohol use disorder with and without other mental disorders and offspring alcohol use disorder

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVE: To investigate whether continued use of non-aspirin NSAID, low-dose aspirin, high-dose aspirin, statins, allopurinol and angiotensin agents decreases the rate of incident depression using Danish nationwide population-based registers.

METHODS: All persons in Denmark who purchased the exposure medications of interest between 1995 and 2015 and a random sample of 30% of the Danish population was included in the study. Two different outcome measures were included, (i) a diagnosis of depressive disorder at a psychiatric hospital as in-patient or out-patient and (ii) a combined measure of a diagnosis of depression or use of antidepressants.

RESULTS: A total of 1 576 253 subjects were exposed to one of the six drugs of interest during the exposure period from 2005 to 2015. Continued use of low-dose aspirin, statins, allopurinol and angiotensin agents was associated with a decreased rate of incident depression according to both outcome measures. Continued uses of non-aspirin NSAIDs as well as high-dose aspirin were associated with an increased rate of incident depression.

CONCLUSION: The findings support the potential of agents acting on inflammation and the stress response system in depression as well as the potential of population-based registers to systematically identify drugs with repurposing potential.

OriginalsprogEngelsk
TidsskriftActa Psychiatrica Scandinavica
Vol/bind139
Udgave nummer1
Sider (fra-til)68-77
Antal sider10
ISSN0001-690X
DOI
StatusUdgivet - jan. 2019

ID: 56121007