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New drug candidates for bipolar disorder-A nation-wide population-based study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Lithium and bipolar depression

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The International Consortium Investigating Neurocognition in Bipolar Disorder (ICONIC-BD)

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Mogens Schou (1918-2005): A scientist, a doctor and a lithium champion

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Lars V Kessing
  • Helene C Rytgaard
  • Thomas A Gerds
  • Michael Berk
  • Claus T Ekstrøm
  • Per K Andersen
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OBJECTIVE: Drug repurposing is an increasingly promising idea in many fields of medicine. We systematically used Danish nation-wide population-based registers to investigate whether continued use of non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs), low-dose aspirin, high-dose aspirin, statins, allopurinol, and angiotensin agents decrease the rate of incident mania/bipolar disorder.

METHODS: A nation-wide population-based longitudinal study using Poisson regression analyses including all persons in Denmark who purchased the exposure medication of interest and a random sample of 30% of the Danish population. The follow-up period comprised a 10 years period from 2005 to 2015. Two different outcome measures were included, (1) a diagnosis of mania/bipolar disorder at a psychiatric hospital contact as inpatient or outpatient and (2) a combined measure of a diagnosis of mania/bipolar disorder or initiation of lithium use.

RESULTS: A total of 1,605,365 subjects were exposed to one of the six drugs of interest during the exposure period from 2005 to 2015, median age 57 years [quartiles: 43;69], and female proportion of 53.1%. Continued use of low-dose aspirin, statins, and angiotensin agents were associated with decreased rates of incident mania/bipolar disorder on both outcome measures. Continued uses of non-aspirin NSAIDs as well as high-dose aspirin were associated with an increased rate of incident bipolar disorder. There were no statistically significant associations for allopurinol.

CONCLUSIONS: The study supports the potential of agents acting on inflammation and the stress response system in bipolar disorder and illustrates that population-based registers can be used to systematically identify drugs with repurposing potentials.

OriginalsprogEngelsk
TidsskriftBipolar Disorders
Vol/bind21
Udgave nummer5
Sider (fra-til)410-418
Antal sider9
ISSN1398-5647
DOI
StatusUdgivet - aug. 2019

Bibliografisk note

© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

ID: 58079098