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Region Hovedstaden - en del af Københavns Universitetshospital
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New Aspects of the Kidney in the Regulation of Fibroblast Growth Factor 23 (FGF23) and Mineral Homeostasis

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

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  1. Diurnal variation of magnesium and the mineral metabolism in patients with chronic kidney disease

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  2. Extrarenal expression of α-klotho, the kidney related longevity gene, in Heterocephalus glaber, the long living Naked Mole Rat

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  3. The Vascular Circadian Clock in Chronic Kidney Disease

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  4. Chronic Kidney Disease-Induced Vascular Calcification Impairs Bone Metabolism

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Vis graf over relationer

The bone-derived hormone fibroblast growth factor 23 (FGF23) acts in concert with parathyroid hormone (PTH) and the active vitamin D metabolite calcitriol in the regulation of calcium (Ca) and phosphate (P) homeostasis. More factors are being identified to regulate FGF23 levels and the endocrine loops between the three hormones. The present review summarizes the complex regulation of FGF23 and the disturbed FGF23/Klotho system in chronic kidney disease (CKD). In addition to the reduced ability of the injured kidney to regulate plasma levels of FGF23, several CKD-related factors have been shown to stimulate FGF23 production. The high circulating FGF23 levels have detrimental effects on erythropoiesis, the cardio-vascular system and the immune system, all contributing to the disturbed system biology in CKD. Moreover, new factors secreted by the injured kidney and the uremic calcified vasculature play a role in the mineral and bone disorder in CKD and create a vicious pathological crosstalk.

OriginalsprogEngelsk
TidsskriftInternational Journal of Molecular Sciences
Vol/bind21
Udgave nummer22
Sider (fra-til)8810
Antal sider20
ISSN1661-6596
DOI
StatusUdgivet - 2 nov. 2020

ID: 61444679