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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Neutralizing antibody response and antibody-dependent cellular cytotoxicity in HIV-1 infected individuals from Guinea-Bissau and Denmark

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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  • Marie Borgren
  • Sanne Skov Jensen
  • Leo Heyndrickx
  • Angelica Palm
  • Jan Gerstoft
  • Gitte Kronborg
  • Bo Langhoff Hønge
  • Sanne Jespersen
  • Zacarias José da Silva
  • Ingrid Karlsson
  • Anders Fomsgaard
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The development of therapeutic and prophylactic HIV vaccines for African countries is urgently needed, but the question of what immunogens to use needs to be answered. One approach is to include HIV envelope immunogens derived from HIV-positive individuals from a geographically concentrated epidemic with more limited viral genetic diversity for a region-based vaccine. To address if there is a basis for a regional selected antibody vaccine, we have screened two regionally separate cohorts from Guinea-Bissau and Denmark for neutralizing antibody activity and antibody-dependent cellular cytotoxicity (ADCC) against local and non-local circulating HIV-1 strains. The neutralizing activity did not demonstrate higher potential against local circulating strains according to geography and subtype determination, but the plasma from Danish individuals demonstrated significantly higher inhibitory activity than the plasma from individuals from Guinea-Bissau against both local and non-local virus strains. Interestingly, an opposite pattern was observed with ADCC activity, where Guinea-Bissau individual plasma demonstrated higher activity than Danish plasma and was specifically against the local circulating subtype. Thus, on basis of samples from these two cohorts no local-specific neutralizing activity was detected, but a local ADCC response was identified in the Guinea-Bissau samples, suggesting potential use of regional immunogens for an ADCC inducing vaccine.

OriginalsprogEngelsk
TidsskriftAIDS Research and Human Retroviruses
Vol/bind32
Udgave nummer5
Sider (fra-til)434-42
ISSN0889-2229
DOI
StatusUdgivet - apr. 2016

ID: 45840152