Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS

Per Soelberg Sørensen; MD Tscherning; Henrik Kahr Mathiesen; Annika  Langkilde; C Ross; Mads Ravnborg; K Bendtzen

doi:10.1212/01.wnl.0000242884.76598.bb

Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS

Per Soelberg Sørensen, MD Tscherning, Henrik Kahr Mathiesen, Annika Langkilde, C Ross, Mads Ravnborg, K Bendtzen

63 Citationer (Scopus)

Abstract

We measured neutralizing antibodies (NABs) and the in vivo biologic response to interferon-beta on neopterin and beta(2)-microglobulin blood levels. All NAB-negative patients had an in vivo biologic response (full or partial), whereas all high-level positive patients had no response. High-level NAB patients had more MRI activity than NAB-negative patients (p = 0.031). Patients with a full response had less MRI activity than patients without biologic response (p = 0.032).

Originalsprog	Engelsk
Tidsskrift	Neurology
Vol/bind	67
Udgave nummer	9
Sider (fra-til)	1681-83
DOI	https://doi.org/10.1212/01.wnl.0000242884.76598.bb
Status	Udgivet - 2006

Adgang til dokumentet

10.1212/01.wnl.0000242884.76598.bb

Citationsformater

@article{e6d1967a175f4476b9796bd5bcf97f75,

title = "Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS",

abstract = "We measured neutralizing antibodies (NABs) and the in vivo biologic response to interferon-beta on neopterin and beta(2)-microglobulin blood levels. All NAB-negative patients had an in vivo biologic response (full or partial), whereas all high-level positive patients had no response. High-level NAB patients had more MRI activity than NAB-negative patients (p = 0.031). Patients with a full response had less MRI activity than patients without biologic response (p = 0.032).",

keywords = "Adult antibodies, antagonists & inhibitors, blood",

author = "S{\o}rensen, {Per Soelberg} and MD Tscherning and {Kahr Mathiesen}, Henrik and Annika Langkilde and C Ross and Mads Ravnborg and K Bendtzen",

year = "2006",

doi = "10.1212/01.wnl.0000242884.76598.bb",

language = "English",

volume = "67",

pages = "1681--83",

journal = "Neurology",

issn = "1526-632X",

publisher = "Lippincott Williams and Wilkins",

number = "9",

}

TY - JOUR

T1 - Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS

AU - Sørensen, Per Soelberg

AU - Tscherning, MD

AU - Kahr Mathiesen, Henrik

AU - Langkilde, Annika

AU - Ross, C

AU - Ravnborg, Mads

AU - Bendtzen, K

PY - 2006

Y1 - 2006

N2 - We measured neutralizing antibodies (NABs) and the in vivo biologic response to interferon-beta on neopterin and beta(2)-microglobulin blood levels. All NAB-negative patients had an in vivo biologic response (full or partial), whereas all high-level positive patients had no response. High-level NAB patients had more MRI activity than NAB-negative patients (p = 0.031). Patients with a full response had less MRI activity than patients without biologic response (p = 0.032).

AB - We measured neutralizing antibodies (NABs) and the in vivo biologic response to interferon-beta on neopterin and beta(2)-microglobulin blood levels. All NAB-negative patients had an in vivo biologic response (full or partial), whereas all high-level positive patients had no response. High-level NAB patients had more MRI activity than NAB-negative patients (p = 0.031). Patients with a full response had less MRI activity than patients without biologic response (p = 0.032).

KW - Adult antibodies

KW - antagonists & inhibitors

KW - blood

U2 - 10.1212/01.wnl.0000242884.76598.bb

DO - 10.1212/01.wnl.0000242884.76598.bb

M3 - Journal article

C2 - 17101906

SN - 1526-632X

VL - 67

SP - 1681

EP - 1683

JO - Neurology

JF - Neurology

IS - 9

ER -

Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater