Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Neuroticism modulates mood responses to pharmacological sex hormone manipulation in healthy women

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Familial associations in hair cortisol concentration: A cross-sectional analysis based on the Healthy Start study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Characteristics influencing expected cognitive performance during hypoglycaemia in type 2 diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Hair cortisol in newly diagnosed bipolar disorder and unaffected first-degree relatives

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Multiple measures of HPA axis function in ultra high risk and first-episode schizophrenia patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Women show increased risk of depressive symptoms during hormonal transition phases. The risk mechanisms may include changes in mood in response to fluctuating ovarian hormones moderated by predisposing risk factors for mood disorders, such as personality trait Neuroticism.

METHODS: A pooled sample of 92 mentally healthy women (28.3 ± 7.1, mean age ± SD) from two independent cohorts run in our lab, using gonadotropin-releasing hormone agonist (GnRHa) experimentally (n = 28) compared to placebo (n = 27) and as part in vitro fertilization (n = 37), were extracted from the Center for Integrated Molecular Brain Imaging database. All women filled in questionnaires of trait Neuroticism from the NEO personality Inventory-Revised (NEO PI-R) at baseline and self-reported levels of mood disturbances with the Profile of Mood States (POMS) daily during 14 days of GnRHa intervention or placebo. Effects of intervention by trait Neuroticism on serial daily reports of mood disturbances were examined using mixed model analyses.

RESULTS: Personality trait Neuroticism significantly modulated daily mood responses to GnRHa, but not placebo. Women with high and low scores on trait Neuroticism at baseline experienced more pronounced changes in mood when exposed to GnRHa, whereas women with medium trait Neuroticism scores remained relatively stable.

CONCLUSIONS: The susceptibility to hormone-triggered mood changes appears to depend upon women's general tendency to experience distress and destabilization of mood, as captured by personality trait Neuroticism. This could aid clinicians evaluate hormone-related vulnerability for mood disorders in women and may guide targeted prevention in reproductive care.

Sider (fra-til)251-256
Antal sider6
StatusUdgivet - 1 jan. 2019

ID: 55573722