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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Neuropeptides and the Nodes of Ranvier in Cranial Headaches

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

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Vis graf over relationer

The trigeminovascular system (TGV) comprise of the trigeminal ganglion with neurons and satellite glial cells, with sensory unmyelinated C-fibers and myelinated Aδ-fibers picking up information from different parts of the head and sending signals to the brainstem and the central nervous system. In this review we discuss aspects of signaling at the distal parts of the sensory fibers, the extrasynaptic signaling between C-fibers and Aδ-fibers, and the contact between the trigeminal fibers at the nerve root entry zone where they transit into the CNS. We also address the possible role of the neuropeptides calcitonin gene-related peptide (CGRP), the neurokinin family and pituitary adenylyl cyclase-activating polypeptide 38 (PACAP-38), all found in the TGV system together with their respective receptors. Elucidation of the expression and localization of neuropeptides and their receptors in the TGV system may provide novel ways to understand their roles in migraine pathophysiology and suggest novel ways for treatment of migraine patients.

OriginalsprogEngelsk
Artikelnummer820037
TidsskriftFrontiers in Physiology
Vol/bind12
Sider (fra-til)820037
ISSN1664-042X
DOI
StatusUdgivet - 2022

Bibliografisk note

Copyright © 2022 Edvinsson, Haanes and Edvinsson.

ID: 74729005