Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Neuromuscular Electrical Stimulation Preserves Leg Lean Mass in Geriatric Patients

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Effects of a Lifestyle Intervention on Bone Turnover in Persons with Type 2 Diabetes: A post hoc Analysis of the U-TURN Trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Threshold of Relative Muscle Power Required to Rise from a Chair and Mobility Limitations and Disability in Older Adults

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Altered Triceps Surae Muscle-Tendon Unit Properties after 6 Months of Static Stretching

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. An Untargeted Urine Metabolomics Approach for Autologous Blood Transfusion Detection

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Relationship of Knee Forces to Subjective Function Pre- and Post-ACL Reconstruction

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Collagen Growth Pattern in Human Articular Cartilage of the Knee

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Mechanical properties of human patellar tendon collagen fibrils. An exploratory study of aging and sex

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

AIM: This study aimed to examine changes in lean mass during hospitalization in geriatric patients and the effect of muscle activation by neuromuscular electrical stimulation.

METHODS: Thirteen patients (69-94 yr) at a geriatric ward completed tests at hospital admission (days 2-3) and discharge (days 8-10). One leg received daily stimulation of the knee extensors, whereas the other leg served as a control leg. Lean mass was evaluated by dual-energy x-ray absorptiometry scans and muscle thickness by ultrasound scans. Muscle biopsies were collected from both legs at admission and discharge in nine patients and analyzed for fiber size, satellite cell number, and activation and expression of genes associated with muscle protein synthesis and breakdown, connective tissue, and cellular stress.

RESULTS: The relative decline in leg lean mass and midthigh region lean mass was larger in the control (-2.8% ± 1.5%) versus the stimulated leg (-0.5% ± 1.4%, P < 0.05). Although there were no changes in fiber size or satellite cell number, the mRNA data revealed that, compared with control, the stimulation resulted in a downregulation of myostatin (P < 0.05) and a similar trend for MAFbx (P = 0.099), together with an upregulation of Collagen I (P < 0.001), TenascinC (P < 0.001), CD68 (P < 0.01), and Ki67 (P < 0.05) mRNA.

CONCLUSION: These findings demonstrate a moderate decline in leg lean mass during a hospital stay in geriatric patients, whereas leg lean mass was preserved with daily neuromuscular electrical muscle activation. At the cellular level, the stimulation had a clear influence on suppression of atrophy signaling pathways in parallel with a stimulation of connective tissue and cellular remodeling processes.

OriginalsprogEngelsk
TidsskriftMedicine and Science in Sports and Exercise
Vol/bind52
Udgave nummer4
Sider (fra-til)773-784
Antal sider12
ISSN0195-9131
DOI
StatusUdgivet - apr. 2020

ID: 64173485