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Neurological prognostication after cardiac arrest and targeted temperature management 33°C versus 36°C: Results from a randomised controlled clinical trial

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Dragancea, Irina ; Horn, Janneke ; Kuiper, Michael ; Friberg, Hans ; Ullén, Susann ; Wetterslev, Jørn ; Cranshaw, Jules ; Hassager, Christian ; Nielsen, Niklas ; Cronberg, Tobias ; TTM trial investigators. / Neurological prognostication after cardiac arrest and targeted temperature management 33°C versus 36°C : Results from a randomised controlled clinical trial. I: Resuscitation. 2015 ; Bind 93. s. 164-170.

Bibtex

@article{831bb63f833348bb8c48b9692c878114,
title = "Neurological prognostication after cardiac arrest and targeted temperature management 33°C versus 36°C: Results from a randomised controlled clinical trial",
abstract = "BACKGROUND: The reliability of some methods of neurological prognostication after out-of-hospital cardiac arrest has been questioned since the introduction of induced hypothermia. The aim of this study was to determine whether different treatment temperatures after resuscitation affected the prognostic accuracy of clinical neurological findings and somatosensory evoked potentials (SSEP) in comatose patients.METHODS: We calculated sensitivity and false positive rate for Glasgow Coma Scale motor score (GCS M), pupillary and corneal reflexes and SSEP to predict poor neurological outcome using prospective data from the Target Temperature Management after Out-of-Hospital Cardiac Arrest Trial which randomised 939 comatose survivors to treatment at either 33°C or 36°C. Poor outcome was defined as severe disability, vegetative state or death (Cerebral Performance Category scale 3-5) at six months.RESULTS: 313 patients (33{\%}) were prognostically assessed; 168 in the 33°C, and 145 in the 36°C group. A GCS M ≤2 had a false positive rate of 19.1{\%} to predict poor outcome due to nine false predictions. Bilaterally absent pupillary reflexes had a false positive rate of 2.1{\%} and absent corneal reflexes had a false positive rate of 2.2{\%} due to one false prediction in each group. The false positive rate for bilaterally absent SSEP N20-peaks was 2.6{\%}.CONCLUSIONS: Bilaterally absent pupillary and corneal reflexes and absent SSEP N20-peaks were reliable markers of a poor prognosis after resuscitation from out-of-hospital cardiac arrest but low GCS M score was not. The reliability of the tests was not altered by the treatment temperature.",
author = "Irina Dragancea and Janneke Horn and Michael Kuiper and Hans Friberg and Susann Ull{\'e}n and J{\o}rn Wetterslev and Jules Cranshaw and Christian Hassager and Niklas Nielsen and Tobias Cronberg and {TTM trial investigators}",
note = "Copyright {\circledC} 2015. Published by Elsevier Ireland Ltd.",
year = "2015",
month = "4",
day = "25",
doi = "10.1016/j.resuscitation.2015.04.013",
language = "English",
volume = "93",
pages = "164--170",
journal = "Resuscitation",
issn = "0300-9572",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Neurological prognostication after cardiac arrest and targeted temperature management 33°C versus 36°C

T2 - Results from a randomised controlled clinical trial

AU - Dragancea, Irina

AU - Horn, Janneke

AU - Kuiper, Michael

AU - Friberg, Hans

AU - Ullén, Susann

AU - Wetterslev, Jørn

AU - Cranshaw, Jules

AU - Hassager, Christian

AU - Nielsen, Niklas

AU - Cronberg, Tobias

AU - TTM trial investigators

N1 - Copyright © 2015. Published by Elsevier Ireland Ltd.

PY - 2015/4/25

Y1 - 2015/4/25

N2 - BACKGROUND: The reliability of some methods of neurological prognostication after out-of-hospital cardiac arrest has been questioned since the introduction of induced hypothermia. The aim of this study was to determine whether different treatment temperatures after resuscitation affected the prognostic accuracy of clinical neurological findings and somatosensory evoked potentials (SSEP) in comatose patients.METHODS: We calculated sensitivity and false positive rate for Glasgow Coma Scale motor score (GCS M), pupillary and corneal reflexes and SSEP to predict poor neurological outcome using prospective data from the Target Temperature Management after Out-of-Hospital Cardiac Arrest Trial which randomised 939 comatose survivors to treatment at either 33°C or 36°C. Poor outcome was defined as severe disability, vegetative state or death (Cerebral Performance Category scale 3-5) at six months.RESULTS: 313 patients (33%) were prognostically assessed; 168 in the 33°C, and 145 in the 36°C group. A GCS M ≤2 had a false positive rate of 19.1% to predict poor outcome due to nine false predictions. Bilaterally absent pupillary reflexes had a false positive rate of 2.1% and absent corneal reflexes had a false positive rate of 2.2% due to one false prediction in each group. The false positive rate for bilaterally absent SSEP N20-peaks was 2.6%.CONCLUSIONS: Bilaterally absent pupillary and corneal reflexes and absent SSEP N20-peaks were reliable markers of a poor prognosis after resuscitation from out-of-hospital cardiac arrest but low GCS M score was not. The reliability of the tests was not altered by the treatment temperature.

AB - BACKGROUND: The reliability of some methods of neurological prognostication after out-of-hospital cardiac arrest has been questioned since the introduction of induced hypothermia. The aim of this study was to determine whether different treatment temperatures after resuscitation affected the prognostic accuracy of clinical neurological findings and somatosensory evoked potentials (SSEP) in comatose patients.METHODS: We calculated sensitivity and false positive rate for Glasgow Coma Scale motor score (GCS M), pupillary and corneal reflexes and SSEP to predict poor neurological outcome using prospective data from the Target Temperature Management after Out-of-Hospital Cardiac Arrest Trial which randomised 939 comatose survivors to treatment at either 33°C or 36°C. Poor outcome was defined as severe disability, vegetative state or death (Cerebral Performance Category scale 3-5) at six months.RESULTS: 313 patients (33%) were prognostically assessed; 168 in the 33°C, and 145 in the 36°C group. A GCS M ≤2 had a false positive rate of 19.1% to predict poor outcome due to nine false predictions. Bilaterally absent pupillary reflexes had a false positive rate of 2.1% and absent corneal reflexes had a false positive rate of 2.2% due to one false prediction in each group. The false positive rate for bilaterally absent SSEP N20-peaks was 2.6%.CONCLUSIONS: Bilaterally absent pupillary and corneal reflexes and absent SSEP N20-peaks were reliable markers of a poor prognosis after resuscitation from out-of-hospital cardiac arrest but low GCS M score was not. The reliability of the tests was not altered by the treatment temperature.

U2 - 10.1016/j.resuscitation.2015.04.013

DO - 10.1016/j.resuscitation.2015.04.013

M3 - Journal article

VL - 93

SP - 164

EP - 170

JO - Resuscitation

JF - Resuscitation

SN - 0300-9572

ER -

ID: 45319838