Neurofilament protein levels in CSF are increased in dementia

L E Rosengren; J E Karlsson; M Sjögren; K Blennow; A Wallin

Neurofilament protein levels in CSF are increased in dementia

L E Rosengren, J E Karlsson, M Sjögren, K Blennow, A Wallin

140 Citationer (Scopus)

Abstract

The neurofilament is the major cytoskeletal structure of myelinated axons. In this study, CSF levels of the light subunit of the neurofilament protein (NFL) were increased in patients with vascular dementia (VAD), AD, and frontotemporal dementia (FTD) compared with neurologically healthy individuals. Because NFL is localized mainly in myelinated axons, these results suggest that the degeneration of white matter in these disorders causes the increased CSF NFL levels.

Originalsprog	Engelsk
Tidsskrift	Neurology
Vol/bind	52
Udgave nummer	5
Sider (fra-til)	1090-3
Antal sider	4
ISSN	0028-3878
Status	Udgivet - 23 mar. 1999
Udgivet eksternt	Ja

Citationsformater

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title = "Neurofilament protein levels in CSF are increased in dementia",

abstract = "The neurofilament is the major cytoskeletal structure of myelinated axons. In this study, CSF levels of the light subunit of the neurofilament protein (NFL) were increased in patients with vascular dementia (VAD), AD, and frontotemporal dementia (FTD) compared with neurologically healthy individuals. Because NFL is localized mainly in myelinated axons, these results suggest that the degeneration of white matter in these disorders causes the increased CSF NFL levels.",

keywords = "Aged, Alzheimer Disease, Dementia, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Neurofilament Proteins, Journal Article, Research Support, Non-U.S. Gov't",

author = "Rosengren, {L E} and Karlsson, {J E} and M Sj{\"o}gren and K Blennow and A Wallin",

year = "1999",

month = mar,

day = "23",

language = "English",

volume = "52",

pages = "1090--3",

journal = "Neurology",

issn = "0028-3878",

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TY - JOUR

T1 - Neurofilament protein levels in CSF are increased in dementia

AU - Rosengren, L E

AU - Karlsson, J E

AU - Sjögren, M

AU - Blennow, K

AU - Wallin, A

PY - 1999/3/23

Y1 - 1999/3/23

N2 - The neurofilament is the major cytoskeletal structure of myelinated axons. In this study, CSF levels of the light subunit of the neurofilament protein (NFL) were increased in patients with vascular dementia (VAD), AD, and frontotemporal dementia (FTD) compared with neurologically healthy individuals. Because NFL is localized mainly in myelinated axons, these results suggest that the degeneration of white matter in these disorders causes the increased CSF NFL levels.

AB - The neurofilament is the major cytoskeletal structure of myelinated axons. In this study, CSF levels of the light subunit of the neurofilament protein (NFL) were increased in patients with vascular dementia (VAD), AD, and frontotemporal dementia (FTD) compared with neurologically healthy individuals. Because NFL is localized mainly in myelinated axons, these results suggest that the degeneration of white matter in these disorders causes the increased CSF NFL levels.

KW - Aged

KW - Alzheimer Disease

KW - Dementia

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Neurofilament Proteins

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Journal article

C2 - 10102440

SN - 0028-3878

VL - 52

SP - 1090

EP - 1093

JO - Neurology

JF - Neurology

IS - 5

ER -

Neurofilament protein levels in CSF are increased in dementia

Abstract

Fingeraftryk

Citationsformater