Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Neural response to emotional faces in monozygotic twins: association with familial risk of affective disorders

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Altered response to risky decisions and reward in patients with obsessive–compulsive disorder

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Anti-inflammatory treatment and risk for depression after first-time stroke in a cohort of 147 487 Danish patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Limited colocalization of microbleeds and microstructural changes after severe traumatic brain injury

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Accessibility of cortical regions to focal TES: Dependence on spatial position, safety, and practical constraints

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Background: Aberrant neural and cognitive response to emotional faces has been observed in people at familial risk of an affective disorder. In this functional MRI study of monozygotic twins, we explored neural correlates of the attentional avoidance of emotional faces that we had previously observed in high-risk versus affected twins, and whether an abnormal neural response to emotional faces represents a risk endophenotype.

Methods: We recruited unaffected monozygotic twins with a co-twin history of mood episodes (high-risk), monozygotic twins with previous mood episodes (affected) and monozygotic twins with no personal or first-degree history of mood episodes (low-risk) between December 2014 and January 2017 based on a nationwide register linkage. Participants viewed fearful and happy faces while performing a gender discrimination task during functional MRI (fMRI) and performed emotional faces dot-probe and facial expression recognition tasks outside the scanner.

Results: A total of 129 monozygotic twins underwent whole-brain fMRI. Highrisk twins (n = 38) displayed greater medial and superior prefrontal response to emotional faces than affected twins (n = 62). This greater activity correlated with stronger attentional avoidance of emotional faces in high-risk twins. In contrast, high-risk and affected twins showed no aberrant neural activity to emotional faces compared with low-risk twins (n = 29).

Limitations: A limitation of this study was its cross-sectional design.

Conclusion: Greater recruitment of the medial and superior prefrontal cortex during implicit emotion processing in high-risk versus affected twins may represent a compensatory or resilience mechanism. In contrast, aberrant neural response to emotional faces does not seem to be a risk endophenotype for affective disorders.

OriginalsprogEngelsk
TidsskriftJournal of psychiatry & neuroscience : JPN
Vol/bind44
Udgave nummer3
Sider (fra-til)1-10
Antal sider10
ISSN1180-4882
DOI
StatusUdgivet - 3 apr. 2019

Bibliografisk note

© 2019 Joule Inc. or its licensors

ID: 56947273