Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Neonatal levels of adiponectin, interleukin-10 and interleukin-12 are associated with the risk of developing type 1 diabetes in childhood and adolescence: A nationwide Danish case-control study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. The lectin pathway of complement: advantage or disadvantage in HIV pathogenesis?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Pre-transplant levels of ficolin-3 are associated with kidney graft survival

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. HETEROGENEITY IN TRAJECTORIES OF GLYCAEMIC CONTROL IN A LARGE COHORT OF CHILDREN AND ADOLESCENTS WITH TYPE-1-DIABETES

    Publikation: KonferencebidragKonferenceabstrakt til konferenceForskningpeer review

  3. Trajectories and predictors of HbA1c in children and adolescents with type 1 diabetes – a Danish nationwide cohort study

    Publikation: KonferencebidragKonferenceabstrakt til konferenceForskningpeer review

  4. Changes in the lipidome in type 1 diabetes following low carbohydrate diet: Post-hoc analysis of a randomized crossover trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND/AIM: An in-depth understanding of the early phase of type 1 diabetes (T1D) pathogenesis is important for targeting primary prevention. We examined if 14 preselected mediators of immune responses differed in neonates that later developed T1D compared to control neonates.

METHODS: The study is a case-control study with a 1:2 matching. The individuals were born between 1981 through 2002. Cases were validated using the National Patient Register and the Danish Childhood Diabetes Register. Interleukin(IL)-1β, IL-4, IL-6, IL-8, IL-10, IL-12p70, interferon gamma, tumor necrosis factor alpha, transforming growth factor beta 1 (active form), leptin, adiponectin, c-reactive protein, mannose-binding lectin and soluble triggering receptor expressed on myeloid cells-1 were measured by using a flowmetric Luminex xMAP® technology. We tested two models both including a number of possible confounders. In the first model (model 1) we also adjusted for HLA-DQB1 genotype. A total of 1930 groups of assay-matched cases and controls (4746 individuals) were included in the statistical analyses.

RESULTS: Adiponectin was negatively associated with later risk of T1D in both models (relative change (RC), model 1: 0.95, P=0.046 and model 2: 0.95, P=0.006). IL-10 and IL-12 were both positively associated with T1D risk in the model 2 (RC, 1.19, P=0.006 and 1.07, P=0.02, respectively)-these results were borderline significant in model 1, but showed the same direction as the results from model 2.

CONCLUSIONS: Our results indicate that specific immunological signatures are already present at time of birth in children developing T1D before the age of 18years.

OriginalsprogEngelsk
TidsskriftClinical immunology (Orlando, Fla.)
Vol/bind174
Sider (fra-til)18-23
Antal sider6
ISSN1521-6616
DOI
StatusUdgivet - jan. 2017

ID: 49833557