N-[2-(maleimido)ethyl]-3-(trimethylstannyl)benzamide, a molecule for radiohalogenation of proteins and peptides

Emma Aneheim; Mark R StJ Foreman; Holger Jensen; Sture Lindegren

doi:10.1016/j.apradiso.2014.11.007

N-[2-(maleimido)ethyl]-3-(trimethylstannyl)benzamide, a molecule for radiohalogenation of proteins and peptides

Emma Aneheim, Mark R StJ Foreman, Holger Jensen, Sture Lindegren

Afdeling for Klinisk Fysiologi og Nuklearmedicin DIA

12 Citationer (Scopus)

Abstract

In this work a new coupling reagent, N-[2-(maleimido)ethyl]-3-(trimethylstannyl)benzamide, for radiohalogenation has been synthesized and characterized. The reagent is intended to either be attached to reduced disulfide bridges of proteins (making the halogenation site-specific) or to free terminal cysteine groups on peptides. The new reagent was also shown to be easily halogenated with inactive bromine and iodine as well as (125)I and (211)At, indicating potential use within targeted radiotherapy.

Originalsprog	Engelsk
Tidsskrift	Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Vol/bind	96
Sider (fra-til)	1-5
Antal sider	5
ISSN	0969-8043
DOI	https://doi.org/10.1016/j.apradiso.2014.11.007
Status	Udgivet - feb. 2015

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N-[2-(maleimido)ethyl]-3-(trimethylstannyl)benzamide, a molecule for radiohalogenation of proteins and peptides. / Aneheim, Emma; Foreman, Mark R StJ; Jensen, Holger et al.
I: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, Bind 96, 02.2015, s. 1-5.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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AU - Aneheim, Emma

AU - Foreman, Mark R StJ

AU - Jensen, Holger

AU - Lindegren, Sture

PY - 2015/2

Y1 - 2015/2

N2 - In this work a new coupling reagent, N-[2-(maleimido)ethyl]-3-(trimethylstannyl)benzamide, for radiohalogenation has been synthesized and characterized. The reagent is intended to either be attached to reduced disulfide bridges of proteins (making the halogenation site-specific) or to free terminal cysteine groups on peptides. The new reagent was also shown to be easily halogenated with inactive bromine and iodine as well as (125)I and (211)At, indicating potential use within targeted radiotherapy.

AB - In this work a new coupling reagent, N-[2-(maleimido)ethyl]-3-(trimethylstannyl)benzamide, for radiohalogenation has been synthesized and characterized. The reagent is intended to either be attached to reduced disulfide bridges of proteins (making the halogenation site-specific) or to free terminal cysteine groups on peptides. The new reagent was also shown to be easily halogenated with inactive bromine and iodine as well as (125)I and (211)At, indicating potential use within targeted radiotherapy.

KW - Astatine

KW - Benzamides

KW - Bromine

KW - Chromatography, High Pressure Liquid

KW - Halogenation

KW - Humans

KW - Indicators and Reagents

KW - Iodine Radioisotopes

KW - Molecular Structure

KW - Organotin Compounds

KW - Peptides

KW - Proteins

KW - Radiopharmaceuticals

UR - https://www.scopus.com/pages/publications/84913555166

U2 - 10.1016/j.apradiso.2014.11.007

DO - 10.1016/j.apradiso.2014.11.007

M3 - Journal article

C2 - 25474765

SN - 0969-8043

VL - 96

SP - 1

EP - 5

JO - Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

JF - Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

ER -

N-[2-(maleimido)ethyl]-3-(trimethylstannyl)benzamide, a molecule for radiohalogenation of proteins and peptides

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