Abstract
Ageing is associated with a reshaping of the immune system characterised by decreased adaptive immunity and systemic low-grade inflammation. These changes are associated with mortality in elderly cohorts and not only important in the defence to infectious diseases but also associated with almost all age-associated chronic diseases such as atherosclerosis, type 2 diabetes and dementia as well as their related risk factors. This review discusses underlying molecular and cellular mechanisms and possible intervention strategy today and in the future.
| Bidragets oversatte titel | When senescence hits the immune system |
|---|---|
| Originalsprog | Dansk |
| Tidsskrift | Ugeskrift for Laeger |
| Vol/bind | 175 |
| Udgave nummer | 47 |
| Sider (fra-til) | 2850-3 |
| Antal sider | 4 |
| ISSN | 0041-5782 |
| Status | Udgivet - 18 nov. 2013 |
| Udgivet eksternt | Ja |
Emneord
- Aging/immunology
- Humans
- Immune System/physiology
- Inflammation/immunology