Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Myeloproliferative Neoplasms in Danish Twins

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Joint Mobility and Physical Function of Danish Hemophilia Patients: A Three-Wave Panel Study Spanning 24 Years

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Haemostasis and safety measures before lumbar puncture in the haematology ward: the Danish routines

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Characteristics and Long-Term Outcome of Patients with Systemic Immunoglobulin Light-Chain Amyloidosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Elevated levels of oxidized nucleosides in individuals with the JAK2V617F mutation from a general population study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Changes in the lipidome in type 1 diabetes following low carbohydrate diet: Post-hoc analysis of a randomized crossover trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Risk of new malignancies among patients with CLL treated with chemotherapy: results of a Danish population-based study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Abnormal eosinophil count at CLL diagnosis correlates with shorter treatment free survival

    Publikation: Bidrag til tidsskriftLetterpeer review

Vis graf over relationer

OBJECTIVE: Myeloproliferative neoplasms (MPNs) are a heterogeneous group of diseases characterized by clonal hyperproliferation of immature and mature cells of the myeloid lineage. Genetic differences have been proposed to play a role in the development of MPNs. Monozygotic twin pairs with MPNs have been reported in a few case reports, but the MPN concordance pattern in twins remains unknown.

METHOD: All twin pairs born in the period 1900-2010 were identified in the nationwide Danish Twin Registry. Only pairs with both twins alive on January 1, 1977, and those born thereafter were included to allow identification in the Danish National Patient Registry.

RESULTS: A total of 158 twin pairs were registered with an MPN diagnosis: 36 monozygotic, 104 dizygotic, and 18 pairs with unknown zygosity. MPNs were diagnosed in both twins in 4 pairs. The probandwise concordance rates for monozygotic twin pairs were higher than for dizygotic twin pairs (15 vs. 0%; p = 0.016).

CONCLUSION: An estimated concordance rate of 15% (95% CI 0.059-0.31) is modest, but given the rarity of MPNs this finding is clinically relevant and provides further support for the role of genetic predisposition in the development of MPNs.

OriginalsprogEngelsk
TidsskriftActa Haematologica
Vol/bind139
Udgave nummer3
Sider (fra-til)195-198
Antal sider4
ISSN0001-5792
DOI
StatusUdgivet - 2018

ID: 56803845