Mutations in sodium channel β-subunit SCN3B are associated with early-onset lone atrial fibrillation

Morten S Olesen, Thomas Jespersen, Jonas B Nielsen, Bo Liang, Daniel V Møller, Paula Hedley, Michael Christiansen, András Varró, Søren-Peter Olesen, Stig Haunsø, Nicole Schmitt, Jesper H Svendsen

    108 Citationer (Scopus)

    Abstract

    Atrial fibrillation (AF) is the most frequent arrhythmia. Screening of SCN5A-the gene encoding the α-subunit of the cardiac sodium channel-has indicated that disturbances of the sodium current may play a central role in the mechanism of lone AF. We tested the hypothesis that lone AF in young patients is associated with genetic mutations in SCN3B and SCN4B, the genes encoding the two β-subunits of the cardiac sodium channel.
    OriginalsprogEngelsk
    TidsskriftCardiovascular Research
    Vol/bind89
    Udgave nummer4
    Sider (fra-til)786-93
    Antal sider8
    ISSN0008-6363
    DOI
    StatusUdgivet - 2011

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