Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa

Rasmus Lykke Marvig, Mette Søndergaard, Søren Damkiær, Niels Høiby, Helle Krogh Johansen, Søren Molin, Lars Jelsbak

27 Citationer (Scopus)

Abstract

The emergence of antibiotic-resistant Pseudomonas aeruginosa is an important concern in the treatment of long-term airway infections in cystic fibrosis patients. In this study, we report the occurrence of azithromycin resistance among clinical P. aeruginosa DK2 isolates. We demonstrate that resistance is associated with specific mutations (A2058G, A2059G, and C2611T in Escherichia coli numbering) in domain V of 23S rRNA and that introduction of A2058G and C2611T into strain PAO1 results in azithromycin resistance.
OriginalsprogEngelsk
TidsskriftAntimicrobial Agents and Chemotherapy
Vol/bind56
Udgave nummer8
Sider (fra-til)4519-21
Antal sider3
ISSN0066-4804
DOI
StatusUdgivet - 2012

Fingeraftryk

Dyk ned i forskningsemnerne om 'Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa'. Sammen danner de et unikt fingeraftryk.

Citationsformater