TY - JOUR
T1 - Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa
AU - Marvig, Rasmus Lykke
AU - Søndergaard, Mette
AU - Damkiær, Søren
AU - Høiby, Niels
AU - Johansen, Helle Krogh
AU - Molin, Søren
AU - Jelsbak, Lars
PY - 2012
Y1 - 2012
N2 - The emergence of antibiotic-resistant Pseudomonas aeruginosa is an important concern in the treatment of long-term airway infections in cystic fibrosis patients. In this study, we report the occurrence of azithromycin resistance among clinical P. aeruginosa DK2 isolates. We demonstrate that resistance is associated with specific mutations (A2058G, A2059G, and C2611T in Escherichia coli numbering) in domain V of 23S rRNA and that introduction of A2058G and C2611T into strain PAO1 results in azithromycin resistance.
AB - The emergence of antibiotic-resistant Pseudomonas aeruginosa is an important concern in the treatment of long-term airway infections in cystic fibrosis patients. In this study, we report the occurrence of azithromycin resistance among clinical P. aeruginosa DK2 isolates. We demonstrate that resistance is associated with specific mutations (A2058G, A2059G, and C2611T in Escherichia coli numbering) in domain V of 23S rRNA and that introduction of A2058G and C2611T into strain PAO1 results in azithromycin resistance.
U2 - 10.1128/AAC.00630-12
DO - 10.1128/AAC.00630-12
M3 - Journal article
C2 - 22644032
VL - 56
SP - 4519
EP - 4521
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 8
ER -