Mutation Load of Single, Large-Scale Deletions of mtDNA in Mitotic and Postmitotic Tissues

Keyphrases

• Mitochondrial DNA 100%
• Large Deletion 100%
• Mitochondrial DNA mutation 100%
• Mutation Load 100%
• Post-mitotic 100%
• Skeletal muscle 40%
• Age of Onset 20%
• Muscle Phenotype 20%
• Tissue Sampling 10%
• No Extensive 10%
• 5′-end 10%
• Epithelial Cells 10%
• Muscle Involvement 10%
• Skeletal muscle Tissue 10%
• Transfer RNA (tRNA) 10%
• Chronic Progressive 10%
• MtDNA mutation 10%
• Eye muscles 10%
• Heteroplasmy 10%
• Buccal mucosa 10%
• Progressive Ophthalmoplegia 10%

Biochemistry, Genetics and Molecular Biology

• Mitochondrial DNA 100%
• Mutational Load 100%
• DNA Mutation 42%
• Skeletal Muscle 28%
• Buccal Mucosa 7%
• Heteroplasmy 7%

Immunology and Microbiology

• Mutational Load 100%
• DNA Mutation 85%
• Skeletal Muscle 57%
• Muscle Tissue 14%
• Buccal Mucosa 14%
• Heteroplasmy 14%