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Muscles adaptation to aging and training: architectural changes - a randomised trial

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Létocart, Adrien J ; Mabesoone, Franck ; Charleux, Fabrice ; Couppé, Christian ; Svensson, René B ; Marin, Frédéric ; Magnusson, S Peter ; Grosset, Jean-François. / Muscles adaptation to aging and training : architectural changes - a randomised trial. I: BMC Geriatrics. 2021 ; Bind 21, Nr. 1. s. 48.

Bibtex

@article{f674d569c0d6401392dccfec388e551a,
title = "Muscles adaptation to aging and training: architectural changes - a randomised trial",
abstract = "BACKGROUND: To investigate how anatomical cross-sectional area and volume of quadriceps and triceps surae muscles were affected by ageing, and by resistance training in older and younger men, in vivo.METHODS: The old participants were randomly assigned to moderate (O55, n = 13) or high-load (O80, n = 14) resistance training intervention (12 weeks; 3 times/week) corresponding to 55% or 80% of one repetition maximum, respectively. Young men (Y55, n = 11) were assigned to the moderate-intensity strengthening exercise program. Each group received the exact same training volume on triceps surae and quadriceps group (Reps x Sets x Intensity). The fitting polynomial regression equations for each of anatomical cross-sectional area-muscle length curves were used to calculate muscle volume (contractile content) before and after 12 weeks using magnetic resonance imaging scans.RESULTS: Only Rectus femoris and medial gastrocnemius muscle showed a higher relative anatomical cross-sectional area in the young than the elderly on the proximal end. The old group displayed a higher absolute volume of non-contractile material than young men in triceps surae (+ 96%). After training, Y55, O55 and O80 showed an increase in total quadriceps (+ 4.3%; + 6.7%; 4.2% respectively) and triceps surae (+ 2.8%; + 7.5%; 4.3% respectively) volume. O55 demonstrated a greater increase on average gains compared to Y55, while no difference between O55 and O80 was observed.CONCLUSIONS: Muscle loss with aging is region-specific for some muscles and uniform for others. Equivalent strength training volume at moderate or high intensities increased muscle volume with no differences in muscle volume gains for old men. These data suggest that physical exercise at moderate intensity (55 to 60% of one repetition maximum) can reverse the aging related loss of muscle mass.TRIAL REGISTRATION: NCT03079180 in ClinicalTrials.gov . Registration date: March 14, 2017.",
keywords = "Ageing, Anatomical cross-sectional area, Muscle volume, Non-contractile tissue, Resistance training",
author = "L{\'e}tocart, {Adrien J} and Franck Mabesoone and Fabrice Charleux and Christian Coupp{\'e} and Svensson, {Ren{\'e} B} and Fr{\'e}d{\'e}ric Marin and Magnusson, {S Peter} and Jean-Fran{\c c}ois Grosset",
year = "2021",
month = jan,
day = "13",
doi = "10.1186/s12877-020-02000-0",
language = "English",
volume = "21",
pages = "48",
journal = "BMC Geriatrics",
issn = "1471-2318",
publisher = "BioMed Central Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Muscles adaptation to aging and training

T2 - architectural changes - a randomised trial

AU - Létocart, Adrien J

AU - Mabesoone, Franck

AU - Charleux, Fabrice

AU - Couppé, Christian

AU - Svensson, René B

AU - Marin, Frédéric

AU - Magnusson, S Peter

AU - Grosset, Jean-François

PY - 2021/1/13

Y1 - 2021/1/13

N2 - BACKGROUND: To investigate how anatomical cross-sectional area and volume of quadriceps and triceps surae muscles were affected by ageing, and by resistance training in older and younger men, in vivo.METHODS: The old participants were randomly assigned to moderate (O55, n = 13) or high-load (O80, n = 14) resistance training intervention (12 weeks; 3 times/week) corresponding to 55% or 80% of one repetition maximum, respectively. Young men (Y55, n = 11) were assigned to the moderate-intensity strengthening exercise program. Each group received the exact same training volume on triceps surae and quadriceps group (Reps x Sets x Intensity). The fitting polynomial regression equations for each of anatomical cross-sectional area-muscle length curves were used to calculate muscle volume (contractile content) before and after 12 weeks using magnetic resonance imaging scans.RESULTS: Only Rectus femoris and medial gastrocnemius muscle showed a higher relative anatomical cross-sectional area in the young than the elderly on the proximal end. The old group displayed a higher absolute volume of non-contractile material than young men in triceps surae (+ 96%). After training, Y55, O55 and O80 showed an increase in total quadriceps (+ 4.3%; + 6.7%; 4.2% respectively) and triceps surae (+ 2.8%; + 7.5%; 4.3% respectively) volume. O55 demonstrated a greater increase on average gains compared to Y55, while no difference between O55 and O80 was observed.CONCLUSIONS: Muscle loss with aging is region-specific for some muscles and uniform for others. Equivalent strength training volume at moderate or high intensities increased muscle volume with no differences in muscle volume gains for old men. These data suggest that physical exercise at moderate intensity (55 to 60% of one repetition maximum) can reverse the aging related loss of muscle mass.TRIAL REGISTRATION: NCT03079180 in ClinicalTrials.gov . Registration date: March 14, 2017.

AB - BACKGROUND: To investigate how anatomical cross-sectional area and volume of quadriceps and triceps surae muscles were affected by ageing, and by resistance training in older and younger men, in vivo.METHODS: The old participants were randomly assigned to moderate (O55, n = 13) or high-load (O80, n = 14) resistance training intervention (12 weeks; 3 times/week) corresponding to 55% or 80% of one repetition maximum, respectively. Young men (Y55, n = 11) were assigned to the moderate-intensity strengthening exercise program. Each group received the exact same training volume on triceps surae and quadriceps group (Reps x Sets x Intensity). The fitting polynomial regression equations for each of anatomical cross-sectional area-muscle length curves were used to calculate muscle volume (contractile content) before and after 12 weeks using magnetic resonance imaging scans.RESULTS: Only Rectus femoris and medial gastrocnemius muscle showed a higher relative anatomical cross-sectional area in the young than the elderly on the proximal end. The old group displayed a higher absolute volume of non-contractile material than young men in triceps surae (+ 96%). After training, Y55, O55 and O80 showed an increase in total quadriceps (+ 4.3%; + 6.7%; 4.2% respectively) and triceps surae (+ 2.8%; + 7.5%; 4.3% respectively) volume. O55 demonstrated a greater increase on average gains compared to Y55, while no difference between O55 and O80 was observed.CONCLUSIONS: Muscle loss with aging is region-specific for some muscles and uniform for others. Equivalent strength training volume at moderate or high intensities increased muscle volume with no differences in muscle volume gains for old men. These data suggest that physical exercise at moderate intensity (55 to 60% of one repetition maximum) can reverse the aging related loss of muscle mass.TRIAL REGISTRATION: NCT03079180 in ClinicalTrials.gov . Registration date: March 14, 2017.

KW - Ageing

KW - Anatomical cross-sectional area

KW - Muscle volume

KW - Non-contractile tissue

KW - Resistance training

UR - http://www.scopus.com/inward/record.url?scp=85099460587&partnerID=8YFLogxK

U2 - 10.1186/s12877-020-02000-0

DO - 10.1186/s12877-020-02000-0

M3 - Journal article

C2 - 33441116

VL - 21

SP - 48

JO - BMC Geriatrics

JF - BMC Geriatrics

SN - 1471-2318

IS - 1

M1 - 48

ER -

ID: 61811029