Muscle Strength and Aerobic Capacity in Patients with CIDP One Year after Participation in an Exercise Trial

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Region Hovedstaden - en del af Københavns Universitetshospital

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Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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@article{704efb2d14714e28b6e513b5ea8a203f,

title = "Muscle Strength and Aerobic Capacity in Patients with CIDP One Year after Participation in an Exercise Trial",

abstract = "BACKGROUND: We have previously shown that patients with chronic inflammatory demyelinating polyneuropathy (CIDP) improve muscle strength and aerobic capacity after resistance and aerobic exercise.OBJECTIVE: The purpose of this study was to determine if muscle strength and aerobic capacity are preserved one year after discontinuation of regular exercise.METHODS: All patients in the previous exercise study were eligible for a one-year follow-up with measurement of combined isokinetic muscle strength (cIKS) by dynamometry and maximal oxygen consumption velocity (VO2-max).RESULTS: Ten of 17 patients accepted to participate in the follow-up study. Following the exercise study six patients discontinued exercise and at one-year follow-up cIKS had decreased by -13.0 {\%} (-25.8 to -2.9) (p = 0.03)) and VO2-max by -16.6 {\%} (-18.8 to -12.6) (p = 0.06). Four patients continued exercise (three with aerobic training and one with resistance training) and at one-year follow-up cIKS and VO2-max were preserved compared to the end of the exercise study (11.6 {\%} (-8.9 to 32.1) (p = 0.88) and -8.4 {\%} (-34.5 to -2.2) (p = 0.13), respectively).CONCLUSIONS: Continuation of aerobic and resistance exercise may preserve gains in muscle strength and aerobic capacity in patients with CIDP.",

keywords = "CIDP, aerobic training, immunoglobulin, muscle strength, resistance training, Muscle Strength Dynamometer, Follow-Up Studies, Humans, Middle Aged, Oxygen Consumption, Male, Treatment Outcome, Exercise Therapy, Exercise Tolerance, Female, Aged, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/physiopathology, Muscle Strength",

author = "Markvardsen, {Lars K} and Carstens, {Anne-Kathrine R} and Knak, {Kirsten L} and Kristian Overgaard and John Vissing and Henning Andersen",

year = "2019",

doi = "10.3233/JND-180344",

language = "English",

volume = "6",

pages = "93--97",

journal = "Journal of Neuromuscular Diseases",

issn = "2214-3599",

publisher = "I O S Press",

number = "1",

}

RIS

TY - JOUR

T1 - Muscle Strength and Aerobic Capacity in Patients with CIDP One Year after Participation in an Exercise Trial

AU - Markvardsen, Lars K

AU - Carstens, Anne-Kathrine R

AU - Knak, Kirsten L

AU - Overgaard, Kristian

AU - Vissing, John

AU - Andersen, Henning

PY - 2019

Y1 - 2019

N2 - BACKGROUND: We have previously shown that patients with chronic inflammatory demyelinating polyneuropathy (CIDP) improve muscle strength and aerobic capacity after resistance and aerobic exercise.OBJECTIVE: The purpose of this study was to determine if muscle strength and aerobic capacity are preserved one year after discontinuation of regular exercise.METHODS: All patients in the previous exercise study were eligible for a one-year follow-up with measurement of combined isokinetic muscle strength (cIKS) by dynamometry and maximal oxygen consumption velocity (VO2-max).RESULTS: Ten of 17 patients accepted to participate in the follow-up study. Following the exercise study six patients discontinued exercise and at one-year follow-up cIKS had decreased by -13.0 % (-25.8 to -2.9) (p = 0.03)) and VO2-max by -16.6 % (-18.8 to -12.6) (p = 0.06). Four patients continued exercise (three with aerobic training and one with resistance training) and at one-year follow-up cIKS and VO2-max were preserved compared to the end of the exercise study (11.6 % (-8.9 to 32.1) (p = 0.88) and -8.4 % (-34.5 to -2.2) (p = 0.13), respectively).CONCLUSIONS: Continuation of aerobic and resistance exercise may preserve gains in muscle strength and aerobic capacity in patients with CIDP.

AB - BACKGROUND: We have previously shown that patients with chronic inflammatory demyelinating polyneuropathy (CIDP) improve muscle strength and aerobic capacity after resistance and aerobic exercise.OBJECTIVE: The purpose of this study was to determine if muscle strength and aerobic capacity are preserved one year after discontinuation of regular exercise.METHODS: All patients in the previous exercise study were eligible for a one-year follow-up with measurement of combined isokinetic muscle strength (cIKS) by dynamometry and maximal oxygen consumption velocity (VO2-max).RESULTS: Ten of 17 patients accepted to participate in the follow-up study. Following the exercise study six patients discontinued exercise and at one-year follow-up cIKS had decreased by -13.0 % (-25.8 to -2.9) (p = 0.03)) and VO2-max by -16.6 % (-18.8 to -12.6) (p = 0.06). Four patients continued exercise (three with aerobic training and one with resistance training) and at one-year follow-up cIKS and VO2-max were preserved compared to the end of the exercise study (11.6 % (-8.9 to 32.1) (p = 0.88) and -8.4 % (-34.5 to -2.2) (p = 0.13), respectively).CONCLUSIONS: Continuation of aerobic and resistance exercise may preserve gains in muscle strength and aerobic capacity in patients with CIDP.

KW - CIDP

KW - aerobic training

KW - immunoglobulin

KW - muscle strength

KW - resistance training

KW - Muscle Strength Dynamometer

KW - Follow-Up Studies

KW - Humans

KW - Middle Aged

KW - Oxygen Consumption

KW - Male

KW - Treatment Outcome

KW - Exercise Therapy

KW - Exercise Tolerance

KW - Female

KW - Aged

KW - Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/physiopathology

KW - Muscle Strength

UR - http://www.scopus.com/inward/record.url?scp=85060995683&partnerID=8YFLogxK

U2 - 10.3233/JND-180344

DO - 10.3233/JND-180344

M3 - Journal article

VL - 6

SP - 93

EP - 97

JO - Journal of Neuromuscular Diseases

JF - Journal of Neuromuscular Diseases

SN - 2214-3599

IS - 1

ER -

ID: 55783259

Muscle Strength and Aerobic Capacity in Patients with CIDP One Year after Participation in an Exercise Trial

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