Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Muscle contractility of leg muscles in patients with mitochondrial myopathies

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Growth and differentiation factor 15 as a biomarker for mitochondrial myopathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Mitochondrial dysfunction underlying outer retinal diseases

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. Hydroxylated Long-Chain Acylcarnitines are Biomarkers of Mitochondrial Myopathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. MSTO1 mutations cause mtDNA depletion, manifesting as muscular dystrophy with cerebellar involvement

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Growth and differentiation factor 15 as a biomarker for mitochondrial myopathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Fat oxidation is impaired during exercise in lipin-1 deficiency

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: The primary disease mechanism underlying mitochondrial myopathies (MM) is impaired energy generation to support muscle endurance. Little is known about muscle contractility before energy becomes deficient during muscle contractions. We investigated muscle contractility in MM to uncover potentially fixed weakness aspects of the disorders.

METHODS: Contractility of calf and thigh muscles was investigated by comparing strength with contractile cross-sectional area (CCSA) of the used muscles, as measured by stationary dynamometry and MRI, respectively.

RESULTS AND DISCUSSION: Our findings suggest reduced contractile properties in thigh and calf muscles of patients with MM.

OriginalsprogEngelsk
TidsskriftMitochondrion
Vol/bind46
Sider (fra-til)221-227
Antal sider7
ISSN1567-7249
DOI
StatusUdgivet - maj 2019

ID: 55680303