Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Muramyl dipeptide responsive pathways in Crohn's disease: from NOD2 and beyond

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. The PCNA interaction motifs revisited: thinking outside the PIP-box

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Investigating the aetiology of adverse events following HPV vaccination with systems vaccinology

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The imidazoline RX871024 induces death of proliferating insulin-secreting cells by activation of c-jun N-terminal kinase

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Crohn's Disease With Progressive Renal Impairment

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  2. Managing vitamin D deficiency in inflammatory bowel disease

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. Metabonomics in Gastroenterology and Hepatology

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
Crohn's disease (CD) is one of main disease entities under the umbrella term chronic inflammatory bowel disease. The etiology of CD involves alterations in genetic, microbiological, and immunological factors. This review is devoted to the role of the bacterial wall compound muramyl dipeptide (MDP) for the activation of inflammatory pathways involved in the pathogenesis of CD. The importance of this molecule is underscored by the fact that (1) MDP, which is found in most Gram-negative and -positive bacteria, is able to trigger several immunological responses in the intestinal system, and (2) that alterations in several mediators of the MDP response including-but not restricted to-nucleotide oligomerization domain 2 (NOD2) are associated with CD. The normalization of MDP signaling is one of several important factors that influence the intestinal inflammatory response, a fact which emphasizes the pathogenic importance of MDP signaling for the pathogenesis of CD. The important aspects of NOD2 and non-NOD2 mediated effects of MDP for the development of CD are highlighted, as well as how alterations in these pathways might translate into the development of new therapeutic strategies.
OriginalsprogEngelsk
TidsskriftCellular and molecular life sciences : CMLS
DOI
StatusUdgivet - 2012

ID: 36596945