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Multivitamin use and risk of preeclampsia in a high-income population: A cohort study

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@article{67a258a9342e4b2eb6946657d6db6e2f,
title = "Multivitamin use and risk of preeclampsia in a high-income population: A cohort study",
abstract = "OBJECTIVE: The objective of this study was to examine the association between multivitamin use in the periconceptional period and the risk of preeclampsia.STUDY DESIGN: The association was investigated in a prospective cohort study. 15,154 deliveries in women followed at a large university hospital in Denmark were included between 16 September 2012 and 31 October 2016. Pregnant women were sent a questionnaire containing items related to socio-demographic-, lifestyle- and health factors. The responses on multivitamin use were merged with the preeclampsia diagnosis from the Danish Medical Birth Registry. We used multiple logistic regression analyses to assess the association and to adjust for potential confounders.MAIN OUTCOME MEASURES: The outcome of interest, preeclampsia, included the preeclampsia subtypes eclampsia and HELLP (Haemolysis, Elevated Liver enzymes, and Low Platelets) syndrome.RESULTS: In total 12,954 women (85{\%}) reported multivitamin use. A diagnosis of preeclampsia was found in 397 women (2.6{\%}). We found a similar risk of preeclampsia in multivitamin user and non-users, adjusted odds ratio (AOR) for periconceptional multivitamin use = 0.97 (95{\%} CI: 0.70 to 1.36) and AOR for early pregnancy multivitamin use = 0.97 (95{\%} CI: 0.71 to 1.32). Subgroup analyses stratified on body mass index showed that among women with overweight, both periconceptional and early pregnancy multivitamin use were associated with a statistically significant lower risk of preeclampsia (AOR = 0.49, 95{\%} CI: 0.24 to 0.99 and AOR = 0.35, 95{\%} CI: 0.18 to 0.69, respectively).CONCLUSION: Periconceptional- and early pregnancy multivitamin use was found to be associated with a similar risk of preeclampsia compared to non-users.",
keywords = "Cohort study, Micronutrients, Multivitamin, Pre-eclampsia, Preconception care, Pregnancy",
author = "Stinne H{\o}gh and Wolf, {Hanne Trap} and {von Euler-Chelpin}, My and Lene Huusom and Anja Pinborg and Ann Tabor and Hegaard, {Hanne Kristine}",
note = "Copyright {\circledC} 2020 Elsevier B.V. All rights reserved.",
year = "2020",
month = "6",
doi = "10.1016/j.srhc.2020.100500",
language = "English",
volume = "24",
journal = "Sexual & Reproductive HealthCare",
issn = "1877-5756",
publisher = "Elsevier Ltd",

}

RIS

TY - JOUR

T1 - Multivitamin use and risk of preeclampsia in a high-income population

T2 - A cohort study

AU - Høgh, Stinne

AU - Wolf, Hanne Trap

AU - von Euler-Chelpin, My

AU - Huusom, Lene

AU - Pinborg, Anja

AU - Tabor, Ann

AU - Hegaard, Hanne Kristine

N1 - Copyright © 2020 Elsevier B.V. All rights reserved.

PY - 2020/6

Y1 - 2020/6

N2 - OBJECTIVE: The objective of this study was to examine the association between multivitamin use in the periconceptional period and the risk of preeclampsia.STUDY DESIGN: The association was investigated in a prospective cohort study. 15,154 deliveries in women followed at a large university hospital in Denmark were included between 16 September 2012 and 31 October 2016. Pregnant women were sent a questionnaire containing items related to socio-demographic-, lifestyle- and health factors. The responses on multivitamin use were merged with the preeclampsia diagnosis from the Danish Medical Birth Registry. We used multiple logistic regression analyses to assess the association and to adjust for potential confounders.MAIN OUTCOME MEASURES: The outcome of interest, preeclampsia, included the preeclampsia subtypes eclampsia and HELLP (Haemolysis, Elevated Liver enzymes, and Low Platelets) syndrome.RESULTS: In total 12,954 women (85%) reported multivitamin use. A diagnosis of preeclampsia was found in 397 women (2.6%). We found a similar risk of preeclampsia in multivitamin user and non-users, adjusted odds ratio (AOR) for periconceptional multivitamin use = 0.97 (95% CI: 0.70 to 1.36) and AOR for early pregnancy multivitamin use = 0.97 (95% CI: 0.71 to 1.32). Subgroup analyses stratified on body mass index showed that among women with overweight, both periconceptional and early pregnancy multivitamin use were associated with a statistically significant lower risk of preeclampsia (AOR = 0.49, 95% CI: 0.24 to 0.99 and AOR = 0.35, 95% CI: 0.18 to 0.69, respectively).CONCLUSION: Periconceptional- and early pregnancy multivitamin use was found to be associated with a similar risk of preeclampsia compared to non-users.

AB - OBJECTIVE: The objective of this study was to examine the association between multivitamin use in the periconceptional period and the risk of preeclampsia.STUDY DESIGN: The association was investigated in a prospective cohort study. 15,154 deliveries in women followed at a large university hospital in Denmark were included between 16 September 2012 and 31 October 2016. Pregnant women were sent a questionnaire containing items related to socio-demographic-, lifestyle- and health factors. The responses on multivitamin use were merged with the preeclampsia diagnosis from the Danish Medical Birth Registry. We used multiple logistic regression analyses to assess the association and to adjust for potential confounders.MAIN OUTCOME MEASURES: The outcome of interest, preeclampsia, included the preeclampsia subtypes eclampsia and HELLP (Haemolysis, Elevated Liver enzymes, and Low Platelets) syndrome.RESULTS: In total 12,954 women (85%) reported multivitamin use. A diagnosis of preeclampsia was found in 397 women (2.6%). We found a similar risk of preeclampsia in multivitamin user and non-users, adjusted odds ratio (AOR) for periconceptional multivitamin use = 0.97 (95% CI: 0.70 to 1.36) and AOR for early pregnancy multivitamin use = 0.97 (95% CI: 0.71 to 1.32). Subgroup analyses stratified on body mass index showed that among women with overweight, both periconceptional and early pregnancy multivitamin use were associated with a statistically significant lower risk of preeclampsia (AOR = 0.49, 95% CI: 0.24 to 0.99 and AOR = 0.35, 95% CI: 0.18 to 0.69, respectively).CONCLUSION: Periconceptional- and early pregnancy multivitamin use was found to be associated with a similar risk of preeclampsia compared to non-users.

KW - Cohort study

KW - Micronutrients

KW - Multivitamin

KW - Pre-eclampsia

KW - Preconception care

KW - Pregnancy

UR - http://www.scopus.com/inward/record.url?scp=85079531436&partnerID=8YFLogxK

U2 - 10.1016/j.srhc.2020.100500

DO - 10.1016/j.srhc.2020.100500

M3 - Journal article

VL - 24

JO - Sexual & Reproductive HealthCare

JF - Sexual & Reproductive HealthCare

SN - 1877-5756

M1 - 100500

ER -

ID: 59408147