Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Multiple measures of HPA axis function in ultra high risk and first-episode schizophrenia patients

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. In utero exposure to maternal stressful life events and risk of polycystic ovary syndrome in the offspring: The Raine Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Familial associations in hair cortisol concentration: A cross-sectional analysis based on the Healthy Start study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Characteristics influencing expected cognitive performance during hypoglycaemia in type 2 diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Neuroticism modulates mood responses to pharmacological sex hormone manipulation in healthy women

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Associations between patterns in comorbid diagnostic trajectories of individuals with schizophrenia and etiological factors

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Pleiotropy between language impairment and broader behavioral disorders-an investigation of both common and rare genetic variants

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Digital Shared Decision-Making Interventions in Mental Healthcare: A Systematic Review and Meta-Analysis

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

INTRODUCTION: Abnormalities within hypothalamus-pituitary-adrenal (HPA) axis might interact with other neurobiological systems to enhance the risk of psychosis. Most of the neurodevelopmental and HPA axis changes occur in adolescence; this is also the period when prodromal and psychotic symptoms occur for the first time. More knowledge about how various stress components interact can advance understanding of the link between psychosis and the HPA axis.

METHOD: We examined 41 ultra high-risk (UHR) patients and 40 antipsychotic-naïve first-episode schizophrenia (FES) patients and compared them with 47 matched controls. The Perceived Stress Scale and the Recent Life Events Questionnaire were used to assess the stress levels. Day-time saliva samples were taken to measure cortisol. The pituitary gland volume was measured manually on the structural MRI using stereology.

RESULTS: Only the UHR patients, had a higher cortisol increase just after awakening (p = 0.009) compared to healthy controls. In UHR patients, we found a negative correlation between cortisol increase after awakening and symptom severity (p = 0.008). Pituitary gland volume and diurnal cortisol were not significantly different among the three groups. There was no correlation between pituitary gland volume, perceived stress/recent life events and any of the cortisol measures or symptoms.

CONCLUSION: Symptom severity during the very early phase of illness (UHR) seems to be associated with altered cortisol increase. Longitudinal studies in UHR patients would be useful to examine how stress levels affect the course of the illness.

OriginalsprogEngelsk
TidsskriftPsychoneuroendocrinology
Vol/bind92
Sider (fra-til)72-80
Antal sider9
ISSN0306-4530
DOI
StatusUdgivet - jun. 2018

ID: 54782992