TY - JOUR
T1 - Multiple inflammatory markers in patients with significant coronary artery disease
AU - Videm, Vibeke
AU - Wiseth, Rune
AU - Gunnes, Sigurd
AU - Madsen, Hans O
AU - Garred, Peter
PY - 2007/5/16
Y1 - 2007/5/16
N2 - BACKGROUND: Several inflammatory biomarkers are linked to cardiovascular risk. In order to investigate their coexistence and relative responses, several established and two novel markers (lactoferrin and the terminal complement complex), representing infection and central components of inflammation, were measured simultaneously in patients undergoing first-time coronary angiography.METHODS AND RESULTS: Blood samples from patients with (n=131) or without (n=103) significant coronary artery stenosis were analyzed for plasma markers representing endothelium, platelets, neutrophils, monocytes, and complement, C-reactive protein, and antibodies against the infectious agents Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus. In multivariate logistic regression analysis, hypercholesterolemia (p<0.001), increased concentrations of the neutrophil activation marker lactoferrin (p<0.001) and the monocyte activation marker neopterin (p=0.012), lower concentrations of the terminal complement complex (p<0.001), and antibodies against C. pneumoniae (p=0.023) were variables linked to coronary artery stenosis. In univariate analysis additional relationships were found to current smoking (p<0.001), increased plasma concentrations of vascular cell adhesion molecule-1 (p=0.015), E-selectin (p<0.01), myeloperoxidase (p=0.051) and endothelin-1 (p=0.053), as well as diabetes (p=0.039).CONCLUSIONS: Activation of multiple inflammatory pathways and C. pneumoniae infection may influence the inflammatory response in atherosclerosis. These pilot data provide an indication of the relative usefulness of various inflammatory biomarkers, indicating that the novel markers lactoferrin and the terminal complement complex warrant further investigation.
AB - BACKGROUND: Several inflammatory biomarkers are linked to cardiovascular risk. In order to investigate their coexistence and relative responses, several established and two novel markers (lactoferrin and the terminal complement complex), representing infection and central components of inflammation, were measured simultaneously in patients undergoing first-time coronary angiography.METHODS AND RESULTS: Blood samples from patients with (n=131) or without (n=103) significant coronary artery stenosis were analyzed for plasma markers representing endothelium, platelets, neutrophils, monocytes, and complement, C-reactive protein, and antibodies against the infectious agents Chlamydia pneumoniae, Helicobacter pylori, and cytomegalovirus. In multivariate logistic regression analysis, hypercholesterolemia (p<0.001), increased concentrations of the neutrophil activation marker lactoferrin (p<0.001) and the monocyte activation marker neopterin (p=0.012), lower concentrations of the terminal complement complex (p<0.001), and antibodies against C. pneumoniae (p=0.023) were variables linked to coronary artery stenosis. In univariate analysis additional relationships were found to current smoking (p<0.001), increased plasma concentrations of vascular cell adhesion molecule-1 (p=0.015), E-selectin (p<0.01), myeloperoxidase (p=0.051) and endothelin-1 (p=0.053), as well as diabetes (p=0.039).CONCLUSIONS: Activation of multiple inflammatory pathways and C. pneumoniae infection may influence the inflammatory response in atherosclerosis. These pilot data provide an indication of the relative usefulness of various inflammatory biomarkers, indicating that the novel markers lactoferrin and the terminal complement complex warrant further investigation.
KW - Analysis of Variance
KW - C-Reactive Protein/metabolism
KW - Chi-Square Distribution
KW - Complement Membrane Attack Complex/metabolism
KW - Coronary Angiography
KW - Coronary Artery Disease/blood
KW - E-Selectin/blood
KW - Endothelin-1/blood
KW - Female
KW - Humans
KW - Inflammation/blood
KW - Intercellular Adhesion Molecule-1/blood
KW - Lactoferrin/blood
KW - Logistic Models
KW - Male
KW - Middle Aged
KW - Neopterin/blood
KW - Peroxidase/blood
KW - Risk Factors
KW - Vascular Cell Adhesion Molecule-1/blood
U2 - 10.1016/j.ijcard.2006.07.005
DO - 10.1016/j.ijcard.2006.07.005
M3 - Journal article
C2 - 16935369
SN - 0167-5273
VL - 118
SP - 81
EP - 87
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 1
ER -