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Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Multi-frequency bioimpedance: a non-invasive tool for muscle-health assessment of adults with cerebral palsy

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Novel insights into cerebral palsy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. An acoustic myography functional assessment of cerebral palsy subjects compared to healthy controls during physical exercise

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Novel insights into cerebral palsy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Muscle contracture development is a major complication for individuals with cerebral palsy (CP) and has lifelong implications. In order to recognize contracture development early and to follow up on preventive interventions aimed at muscle health development, non-invasive, and easy to use methods are needed. The aim of the present study was to assess whether multi-frequency Bioimpedance (mfBIA) can be used to detect differences between skeletal muscle of individuals with CP and healthy controls. The mfBIA technique was applied to the medial gastrocnemius muscle of n = 24 adults with CP and n = 20 healthy controls of both genders. The phase angle (PA) and the centre frequency (fc) were significantly lower in individuals with CP when compared to controls; PA: - 25% for women and - 31.8% for men (P < 0.0001); fc: - 5.6% for women and - 5.2% for men (P < 0.009). The reactance (Xc) and the extracellular resistance (Re) of skeletal muscle from individuals with CP were significantly higher when compared to controls; Xc: + 9.9% for women and + 28.9% for men (P < 0.0001); Re: + 39.7% for women and + 91.2% for men (P < 0.0001). The present study shows that several mfBIA parameters differ significantly between individuals with CP and healthy controls. Furthermore, these changes correlated significantly with the severity of CP, as assessed using the GMFCS scale. The present data indicate that mfBIA shows promise in terms of being a useful diagnostic tool, capable of characterizing muscle health and its development in individuals with cerebral palsy.

OriginalsprogEngelsk
TidsskriftJournal of muscle research and cell motility
ISSN0142-4319
DOI
StatusE-pub ahead of print - 27 mar. 2020

ID: 59836669