Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Combined burden and functional impact tests for cancer driver discovery using DriverPower

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Genomic footprints of activated telomere maintenance mechanisms in cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Pathway and network analysis of more than 2500 whole cancer genomes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Prenatal dietary supplements influence the infant airway microbiota in a randomized factorial clinical trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Carotid-femoral pulse wave velocity is a risk marker for complications in persons with type 1 diabetes

    Publikation: KonferencebidragKonferenceabstrakt til konferenceForskning

  2. Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children with asthma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Annah B Wyss
  • Tamar Sofer
  • Mi Kyeong Lee
  • Natalie Terzikhan
  • Jennifer N Nguyen
  • Lies Lahousse
  • Jeanne C Latourelle
  • Albert Vernon Smith
  • Traci M Bartz
  • Mary F Feitosa
  • Wei Gao
  • Tarunveer S Ahluwalia
  • Wenbo Tang
  • Christopher Oldmeadow
  • Qing Duan
  • Kim de Jong
  • Mary K Wojczynski
  • Xin-Qun Wang
  • Raymond Noordam
  • Fernando Pires Hartwig
  • Victoria E Jackson
  • Tianyuan Wang
  • Ma'en Obeidat
  • Brian D Hobbs
  • Tianxiao Huan
  • Hongsheng Gui
  • Margaret M Parker
  • Donglei Hu
  • Lauren S Mogil
  • Gleb Kichaev
  • Jianping Jin
  • Mariaelisa Graff
  • Tamara B Harris
  • Ravi Kalhan
  • Susan R Heckbert
  • Lavinia Paternoster
  • Kristin M Burkart
  • Yongmei Liu
  • Elizabeth G Holliday
  • James G Wilson
  • Judith M Vonk
  • Jason L Sanders
  • R Graham Barr
  • Renée de Mutsert
  • Ana Maria Baptista Menezes
  • Hieab H H Adams
  • Maarten van den Berge
  • Roby Joehanes
  • Albert M Levin
  • Jennifer Liberto
  • Lenore J Launer
  • Alanna C Morrison
  • Colleen M Sitlani
  • Juan C Celedón
  • Stephen B Kritchevsky
  • Rodney J Scott
  • Kaare Christensen
  • Jerome I Rotter
  • Tobias N Bonten
  • Fernando César Wehrmeister
  • Yohan Bossé
  • Shujie Xiao
  • Sam Oh
  • Nora Franceschini
  • Jennifer A Brody
  • Robert C Kaplan
  • Kurt Lohman
  • Mark McEvoy
  • Michael A Province
  • Frits R Rosendaal
  • Kent D Taylor
  • David C Nickle
  • L Keoki Williams
  • Esteban G Burchard
  • Heather E Wheeler
  • Don D Sin
  • Vilmundur Gudnason
  • Kari E North
  • Myriam Fornage
  • Bruce M Psaty
  • Richard H Myers
  • George O'Connor
  • Torben Hansen
  • Cathy C Laurie
  • Patricia A Cassano
  • Joohon Sung
  • Woo Jin Kim
  • John R Attia
  • Leslie Lange
  • H Marike Boezen
  • Bharat Thyagarajan
  • Stephen S Rich
  • Dennis O Mook-Kanamori
  • Bernardo Lessa Horta
  • André G Uitterlinden
  • Hae Kyung Im
  • Michael H Cho
  • Guy G Brusselle
  • Sina A Gharib
  • Josée Dupuis
  • Ani Manichaikul
  • Stephanie J London
Vis graf over relationer

Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European (N = 60,552), African (N = 8429), Asian (N = 9959), and Hispanic/Latino (N = 11,775) ethnicities. We identify over 50 additional loci at genome-wide significance in ancestry-specific or multiethnic meta-analyses. Using recent fine-mapping methods incorporating functional annotation, gene expression, and differences in linkage disequilibrium between ethnicities, we further shed light on potential causal variants and genes at known and newly identified loci. Several of the novel genes encode proteins with predicted or established drug targets, including KCNK2 and CDK12. Our study highlights the utility of multiethnic and integrative genomics approaches to extend existing knowledge of the genetics of lung function and clinical relevance of implicated loci.

OriginalsprogEngelsk
TidsskriftNature Communications
Vol/bind9
Udgave nummer1
Sider (fra-til)2976
ISSN2041-1723
DOI
StatusUdgivet - 30 jul. 2018

ID: 54964277