Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017

David Terkelsen; Jacob Tolstrup; Camilla Hundahl Johnsen; Ole Lund; Helle Kiellberg Larsen; Peder Worning; Magnus Unemo; Henrik Westh

doi:10.2807/1560-7917.ES.2017.22.42.17-00659

Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017

David Terkelsen, Jacob Tolstrup, Camilla Hundahl Johnsen, Ole Lund, Helle Kiellberg Larsen, Peder Worning, Magnus Unemo, Henrik Westh

86 Citationer (Scopus)

Abstract

We describe a multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.

Originalsprog	Engelsk
Tidsskrift	Eurosurveillance
Vol/bind	22
Udgave nummer	42
ISSN	1560-7917
DOI	https://doi.org/10.2807/1560-7917.ES.2017.22.42.17-00659
Status	Udgivet - okt. 2017

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abstract = "We describe a multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.",

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AU - Terkelsen, David

AU - Tolstrup, Jacob

AU - Johnsen, Camilla Hundahl

AU - Lund, Ole

AU - Larsen, Helle Kiellberg

AU - Worning, Peder

AU - Unemo, Magnus

AU - Westh, Henrik

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N2 - We describe a multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.

AB - We describe a multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Denmark, 2017. Whole genome sequencing of the strain GK124 identified MSLT ST1903, NG-MAST ST1614 and all relevant resistance determinants including similar penA resistance mutations previously described in ceftriaxone-resistant gonococcal strains. Although treatment with ceftriaxone 0.5 g plus azithromycin 2 g was successful, increased awareness of spread of gonococcal strains threatening the recommended dual therapy is crucial.

KW - Journal Article

UR - https://www.scopus.com/pages/publications/85032000612

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DO - 10.2807/1560-7917.ES.2017.22.42.17-00659

M3 - Journal article

C2 - 29067905

SN - 1560-7917

VL - 22

JO - Eurosurveillance

JF - Eurosurveillance

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ER -

Multidrug-resistant Neisseria gonorrhoeae infection with ceftriaxone resistance and intermediate resistance to azithromycin, Denmark, 2017

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