Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Multidimensional diffusion MRI with spectrally modulated gradients reveals unprecedented microstructural detail

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Body mass index in young men and risk of inflammatory bowel disease through adult life: A population-based Danish cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Antibiotic use during pregnancy and childhood overweight: A population-based nationwide cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Muscle fibre morphology and microarchitecture in cerebral palsy patients obtained by 3D synchrotron X-ray computed tomography

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Limits to anatomical accuracy of diffusion tractography using modern approaches

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Topological principles and developmental algorithms might refine diffusion tractography

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  5. Imaging brain microstructure with diffusion MRI: practicality and applications

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

Characterization of porous media is essential in a wide range of biomedical and industrial applications. Microstructural features can be probed non-invasively by diffusion magnetic resonance imaging (dMRI). However, diffusion encoding in conventional dMRI may yield similar signatures for very different microstructures, which represents a significant limitation for disentangling individual microstructural features in heterogeneous materials. To solve this problem, we propose an augmented multidimensional diffusion encoding (MDE) framework, which unlocks a novel encoding dimension to assess time-dependent diffusion specific to structures with different microscopic anisotropies. Our approach relies on spectral analysis of complex but experimentally efficient MDE waveforms. Two independent contrasts to differentiate features such as cell shape and size can be generated directly by signal subtraction from only three types of measurements. Analytical calculations and simulations support our experimental observations. Proof-of-concept experiments were applied on samples with known and distinctly different microstructures. We further demonstrate substantially different contrasts in different tissue types of a post mortem brain. Our simultaneous assessment of restriction size and shape may be instrumental in studies of a wide range of porous materials, enable new insights into the microstructure of biological tissues or be of great value in diagnostics.

OriginalsprogEngelsk
Artikelnummer9026
TidsskriftScientific Reports
Vol/bind9
ISSN2045-2322
DOI
StatusUdgivet - 21 jun. 2019

ID: 57418622