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Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Multicenter R2* mapping in the healthy brain

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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  • Stefan Ropele
  • Mike P Wattjes
  • Christian Langkammer
  • Iris D Kilsdonk
  • Wolter L de Graaf
  • Jette L Frederiksen
  • Dan Fuglø
  • Marios Yiannakas
  • Claudia A M Wheeler-Kingshott
  • Christian Enzinger
  • Maria A Rocca
  • Till Sprenger
  • Michael Amman
  • Ludwig Kappos
  • Massimo Filippi
  • Alex Rovira
  • Olga Ciccarelli
  • Frederik Barkhof
  • Franz Fazekas
Vis graf over relationer
PURPOSE: The R2* relaxation rate constant has been suggested as a sensitive measure for iron accumulation. The aim of this multi-center study was to assess the inter-scanner and inter-subject variability of R2* mapping and to investigate the relationship between brain volume and R2* in specific structures. METHODS: R2* mapping was performed in 81 healthy subjects in seven centers using different 3 T systems. R2* was calculated from a dual-echo gradient echo sequence and was assessed in several deep gray matter structures. The inter-scanner and inter-subject variability of R2* was calculated by means of the coefficient of variation before and after correcting for age. RESULTS: Significant center effects were seen in some regions which get lost after age correction. The coefficient of variation for the inter-center variability was much lower (
OriginalsprogEngelsk
TidsskriftMagnetic Resonance in Medicine
Vol/bind71
Udgave nummer3
Sider (fra-til)1103–1107
ISSN0740-3194
DOI
StatusE-pub ahead of print - 2014

ID: 38661833