Multicenter R2* mapping in the healthy brain

Stefan Ropele; Mike P Wattjes; Christian Langkammer; Iris D Kilsdonk; Wolter L de Graaf; Jette L Frederiksen; Dan Fuglø; Marios Yiannakas; Claudia A M Wheeler-Kingshott; Christian Enzinger; Maria A Rocca; Till Sprenger; Michael Amman; Ludwig Kappos; Massimo Filippi; Alex Rovira; Olga Ciccarelli; Frederik Barkhof; Franz Fazekas

doi:10.1002/mrm.24772

Multicenter R2* mapping in the healthy brain

Stefan Ropele, Mike P Wattjes, Christian Langkammer, Iris D Kilsdonk, Wolter L de Graaf, Jette L Frederiksen, Dan Fuglø, Marios Yiannakas, Claudia A M Wheeler-Kingshott, Christian Enzinger, Maria A Rocca, Till Sprenger, Michael Amman, Ludwig Kappos, Massimo Filippi, Alex Rovira, Olga Ciccarelli, Frederik Barkhof, Franz Fazekas

17 Citationer (Scopus)

Abstract

PURPOSE: The R2* relaxation rate constant has been suggested as a sensitive measure for iron accumulation. The aim of this multi-center study was to assess the inter-scanner and inter-subject variability of R2* mapping and to investigate the relationship between brain volume and R2* in specific structures. METHODS: R2* mapping was performed in 81 healthy subjects in seven centers using different 3 T systems. R2* was calculated from a dual-echo gradient echo sequence and was assessed in several deep gray matter structures. The inter-scanner and inter-subject variability of R2* was calculated by means of the coefficient of variation before and after correcting for age. RESULTS: Significant center effects were seen in some regions which get lost after age correction. The coefficient of variation for the inter-center variability was much lower (

Originalsprog	Engelsk
Tidsskrift	Magnetic Resonance in Medicine
Vol/bind	71
Udgave nummer	3
Sider (fra-til)	1103–1107
ISSN	0740-3194
DOI	https://doi.org/10.1002/mrm.24772
Status	E-pub ahead of print - 2014

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10.1002/mrm.24772

Citationsformater

Ropele, S., Wattjes, M. P., Langkammer, C., Kilsdonk, I. D., de Graaf, W. L., Frederiksen, J. L., Fuglø, D., Yiannakas, M., Wheeler-Kingshott, C. A. M., Enzinger, C., Rocca, M. A., Sprenger, T., Amman, M., Kappos, L., Filippi, M., Rovira, A., Ciccarelli, O., Barkhof, F., & Fazekas, F. (2014). Multicenter R2* mapping in the healthy brain. Magnetic Resonance in Medicine, 71(3), 1103–1107. Advance online publication. https://doi.org/10.1002/mrm.24772

Ropele, S, Wattjes, MP, Langkammer, C, Kilsdonk, ID, de Graaf, WL, Frederiksen, JL , Fuglø, D, Yiannakas, M, Wheeler-Kingshott, CAM, Enzinger, C, Rocca, MA, Sprenger, T, Amman, M, Kappos, L, Filippi, M, Rovira, A, Ciccarelli, O, Barkhof, F & Fazekas, F 2014, 'Multicenter R2* mapping in the healthy brain', Magnetic Resonance in Medicine, bind 71, nr. 3, s. 1103–1107. https://doi.org/10.1002/mrm.24772

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title = "Multicenter R2* mapping in the healthy brain",

abstract = "PURPOSE: The R2* relaxation rate constant has been suggested as a sensitive measure for iron accumulation. The aim of this multi-center study was to assess the inter-scanner and inter-subject variability of R2* mapping and to investigate the relationship between brain volume and R2* in specific structures. METHODS: R2* mapping was performed in 81 healthy subjects in seven centers using different 3 T systems. R2* was calculated from a dual-echo gradient echo sequence and was assessed in several deep gray matter structures. The inter-scanner and inter-subject variability of R2* was calculated by means of the coefficient of variation before and after correcting for age. RESULTS: Significant center effects were seen in some regions which get lost after age correction. The coefficient of variation for the inter-center variability was much lower (",

author = "Stefan Ropele and Wattjes, {Mike P} and Christian Langkammer and Kilsdonk, {Iris D} and {de Graaf}, {Wolter L} and Frederiksen, {Jette L} and Dan Fugl{\o} and Marios Yiannakas and Wheeler-Kingshott, {Claudia A M} and Christian Enzinger and Rocca, {Maria A} and Till Sprenger and Michael Amman and Ludwig Kappos and Massimo Filippi and Alex Rovira and Olga Ciccarelli and Frederik Barkhof and Franz Fazekas",

note = "Copyright {\textcopyright} 2013 Wiley Periodicals, Inc.",

year = "2014",

doi = "10.1002/mrm.24772",

language = "English",

volume = "71",

pages = "1103–1107",

journal = "Magnetic Resonance in Medicine",

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T1 - Multicenter R2* mapping in the healthy brain

AU - Ropele, Stefan

AU - Wattjes, Mike P

AU - Langkammer, Christian

AU - Kilsdonk, Iris D

AU - de Graaf, Wolter L

AU - Frederiksen, Jette L

AU - Fuglø, Dan

AU - Yiannakas, Marios

AU - Wheeler-Kingshott, Claudia A M

AU - Enzinger, Christian

AU - Rocca, Maria A

AU - Sprenger, Till

AU - Amman, Michael

AU - Kappos, Ludwig

AU - Filippi, Massimo

AU - Rovira, Alex

AU - Ciccarelli, Olga

AU - Barkhof, Frederik

AU - Fazekas, Franz

PY - 2014

Y1 - 2014

N2 - PURPOSE: The R2* relaxation rate constant has been suggested as a sensitive measure for iron accumulation. The aim of this multi-center study was to assess the inter-scanner and inter-subject variability of R2* mapping and to investigate the relationship between brain volume and R2* in specific structures. METHODS: R2* mapping was performed in 81 healthy subjects in seven centers using different 3 T systems. R2* was calculated from a dual-echo gradient echo sequence and was assessed in several deep gray matter structures. The inter-scanner and inter-subject variability of R2* was calculated by means of the coefficient of variation before and after correcting for age. RESULTS: Significant center effects were seen in some regions which get lost after age correction. The coefficient of variation for the inter-center variability was much lower (

AB - PURPOSE: The R2* relaxation rate constant has been suggested as a sensitive measure for iron accumulation. The aim of this multi-center study was to assess the inter-scanner and inter-subject variability of R2* mapping and to investigate the relationship between brain volume and R2* in specific structures. METHODS: R2* mapping was performed in 81 healthy subjects in seven centers using different 3 T systems. R2* was calculated from a dual-echo gradient echo sequence and was assessed in several deep gray matter structures. The inter-scanner and inter-subject variability of R2* was calculated by means of the coefficient of variation before and after correcting for age. RESULTS: Significant center effects were seen in some regions which get lost after age correction. The coefficient of variation for the inter-center variability was much lower (

U2 - 10.1002/mrm.24772

DO - 10.1002/mrm.24772

M3 - Journal article

C2 - 23657963

SN - 0740-3194

VL - 71

SP - 1103

EP - 1107

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

IS - 3

ER -

Multicenter R2* mapping in the healthy brain

Abstract

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