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Region Hovedstaden - en del af Københavns Universitetshospital

Multicenter European Prevalence Study of Neurocognitive Impairment and Associated Factors in HIV Positive Patients

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


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  • Lewis J Haddow
  • Rosanna Laverick
  • Marina Daskalopoulou
  • Jeffrey McDonnell
  • Fiona C Lampe
  • Richard Gilson
  • Andrew Speakman
  • Andrea Antinori
  • Pietro Balestra
  • Tina Bruun
  • Jan Gerstoft
  • Lars Nørregård Nielsen
  • Anna Vassilenko
  • Simon Collins
  • Alison J Rodger
  • Cognitive Impairment in People with HIV in the European Region (CIPHER) Study Group
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We conducted a cross-sectional study in 448 HIV positive patients attending five European outpatient clinics to determine prevalence of and factors associated with neurocognitive impairment (NCI) using computerized and pen-and-paper neuropsychological tests. NCI was defined as a normalized Z score ≤-1 in at least 2 out of 5 cognitive domains. Participants' mean age was 45.8 years; 84% male; 87% white; 56% university educated; median CD4 count 550 cells/mm(3); 89% on antiretroviral therapy. 156 (35%) participants had NCI, among whom 26 (17%; 5.8% overall) reported a decline in activities of daily living. Prevalence of NCI was lower in those always able to afford basic needs (adjusted prevalence ratio [aPR] 0.71, 95% confidence interval [CI] 0.54-0.94) or with a university education (aPR 0.72, 95% CI 0.54-0.97) and higher in those with severe depressive symptoms (aPR 1.53, 95% CI 1.09-2.14) or a significant comorbid condition (aPR 1.40, 95% CI 1.03-1.90).

TidsskriftAIDS and Behavior
Sider (fra-til)Open access
StatusUdgivet - 2017

ID: 49784987