Multi-drug-resistant tuberculosis in HIV positive patients in Eastern Europe

Frank A Post, Daniel Grint, Anne Marie Werlinrud, Alexander Panteleev, Vieja Riekstina, Evgeniy A Malashenkov, Alena Skrahina, Dan Duiculescu, Daria Podlekareva, Igor Karpov, Vasiliy Bondarenko, Nelly Chentsova, Jens Lundgren, Amanda Mocroft, Ole Kirk, Jose M Miro, HIV-TB Study Group

    34 Citationer (Scopus)

    Abstrakt

    Observational data from Eastern Europe on the management and outcome of multi-drug-resistant tuberculosis (MDR TB) in HIV positive populations remain sparse in the English-language literature. We compared clinical characteristics and outcomes of 55 patients who were diagnosed with HIV and MDR TB in Eastern Europe between 2004 and 2006 to 89 patients whose Mycobacterium tuberculosis isolates were susceptible to isoniazid and rifampicin. Patients with HIV and MDR TB were young and predominantly male with high rates of intravenous drug use, imprisonment and hepatitis C co-infection. Eighty-four per cent of patients with MDR TB had no history of previous TB drug exposure suggesting that the majority of MDR TB resulted from transmission of drug-resistant M. tuberculosis. The use of non-standardized tuberculosis treatment was common, and the use of antiretroviral therapy infrequent. Compared to those with susceptible tuberculosis, patients with MDR TB were less likely to achieve cure or complete tuberculosis treatment (21.8% vs. 62.9%, p 
    OriginalsprogEngelsk
    TidsskriftJournal of Infection
    Vol/bind68
    Udgave nummer3
    Sider (fra-til)259-63
    ISSN0163-4453
    DOI
    StatusUdgivet - 2014

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