Mulig terapeutisk intervention med haemmere og fremmere af fosfolipase A 2 -subtyper

Miriam Kolko; Chen Zhan; Jens Rovelt Andreasen; Jan Ulrik Prause; Steffen Heegaard

Mulig terapeutisk intervention med haemmere og fremmere af fosfolipase A 2 -subtyper

Miriam Kolko, Chen Zhan, Jens Rovelt Andreasen, Jan Ulrik Prause, Steffen Heegaard

Abstract

Phospholipase A2 (PLA2) is a group of enzymes discovered more than a century ago in insect and snake poison. Not more than 20 years ago they were identified in vertebrates, and during the last five years, research has accelerated in relation to isolating and cloning several members of this super-family in humans. PLA2 inhibitors are in the process of being developed for pharmaceutical use. The purpose of this review is to outline the relevance and prospectives of PLA2 in a clinical perspective.

Bidragets oversatte titel	Possible therapeutic intervention with inhibitors and promoters of phospholipase A2 subtypes
Originalsprog	Dansk
Tidsskrift	Ugeskrift for Laeger
Vol/bind	169
Udgave nummer	2
Sider (fra-til)	115-9
Antal sider	5
ISSN	0041-5782
Status	Udgivet - 8 jan. 2007
Udgivet eksternt	Ja

Emneord

Brain Diseases/drug therapy
Cardiovascular Diseases/drug therapy
Enzyme Inhibitors/therapeutic use
Humans
Inflammation/drug therapy
Neoplasms/drug therapy
Phospholipases A/antagonists & inhibitors
Phospholipases A2

Citationsformater

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title = "Mulig terapeutisk intervention med haemmere og fremmere af fosfolipase A 2 -subtyper",

abstract = "Phospholipase A2 (PLA2) is a group of enzymes discovered more than a century ago in insect and snake poison. Not more than 20 years ago they were identified in vertebrates, and during the last five years, research has accelerated in relation to isolating and cloning several members of this super-family in humans. PLA2 inhibitors are in the process of being developed for pharmaceutical use. The purpose of this review is to outline the relevance and prospectives of PLA2 in a clinical perspective.",

keywords = "Brain Diseases/drug therapy, Cardiovascular Diseases/drug therapy, Enzyme Inhibitors/therapeutic use, Humans, Inflammation/drug therapy, Neoplasms/drug therapy, Phospholipases A/antagonists & inhibitors, Phospholipases A2",

author = "Miriam Kolko and Chen Zhan and Andreasen, {Jens Rovelt} and Prause, {Jan Ulrik} and Steffen Heegaard",

year = "2007",

month = jan,

day = "8",

language = "Dansk",

volume = "169",

pages = "115--9",

journal = "Ugeskrift for Laeger",

issn = "0041-5782",

publisher = "Almindelige Danske Laegeforening",

number = "2",

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TY - JOUR

T1 - Mulig terapeutisk intervention med haemmere og fremmere af fosfolipase A 2 -subtyper

AU - Kolko, Miriam

AU - Zhan, Chen

AU - Andreasen, Jens Rovelt

AU - Prause, Jan Ulrik

AU - Heegaard, Steffen

PY - 2007/1/8

Y1 - 2007/1/8

N2 - Phospholipase A2 (PLA2) is a group of enzymes discovered more than a century ago in insect and snake poison. Not more than 20 years ago they were identified in vertebrates, and during the last five years, research has accelerated in relation to isolating and cloning several members of this super-family in humans. PLA2 inhibitors are in the process of being developed for pharmaceutical use. The purpose of this review is to outline the relevance and prospectives of PLA2 in a clinical perspective.

AB - Phospholipase A2 (PLA2) is a group of enzymes discovered more than a century ago in insect and snake poison. Not more than 20 years ago they were identified in vertebrates, and during the last five years, research has accelerated in relation to isolating and cloning several members of this super-family in humans. PLA2 inhibitors are in the process of being developed for pharmaceutical use. The purpose of this review is to outline the relevance and prospectives of PLA2 in a clinical perspective.

KW - Brain Diseases/drug therapy

KW - Cardiovascular Diseases/drug therapy

KW - Enzyme Inhibitors/therapeutic use

KW - Humans

KW - Inflammation/drug therapy

KW - Neoplasms/drug therapy

KW - Phospholipases A/antagonists & inhibitors

KW - Phospholipases A2

M3 - Review

C2 - 17227656

SN - 0041-5782

VL - 169

SP - 115

EP - 119

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 2

ER -

Mulig terapeutisk intervention med haemmere og fremmere af fosfolipase A 2 -subtyper

Abstract

Emneord

Fingeraftryk

Citationsformater