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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Mucosal microRNAs relate to age and severity of disease in ulcerative colitis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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Vis graf over relationer

Despite significant evidence that the expression of several microRNAs (miRNAs) impacts disease activity in patients with ulcerative colitis (UC), it remains unknown if the more severe disease phenotype seen in pediatric onset UC can be explained by an altered miRNA expression. In this study, we assessed the relationship between miRNA expression, age, and disease severity in pediatric and adult patients with UC. Using RT-qPCR, we analyzed the expression of miR-21, miR-31, miR-126, miR-142 and miR-155 in paraffin embedded rectum biopsies from 30 pediatric and 30 adult-onset UC patients. We found that lesions from adult patients had significantly higher expression levels of miR-21 compared to pediatric patients and that the expression levels of miR-31 (all patients) and miR-155 (pediatric patients only) correlated inversely with histological assessed disease severity. Using in situ hybridization followed by image analysis, the expression level estimates of miR-21 and miR-126 correlated with histological assessed disease severity. In conclusion, we found that the expression of miRNAs depends on the age of the patient and/or the severity of the disease, suggesting that miRNAs may contribute to the regulation of inflammation in UC and could be useful biomarkers in the surveillance of disease severity.

OriginalsprogEngelsk
TidsskriftAging
Vol/bind13
Udgave nummer5
Sider (fra-til)6359-6374
Antal sider16
ISSN1945-4589
DOI
StatusUdgivet - 1 mar. 2021

Bibliografisk note

Funding Information:
This study was supported by the “Overlaege Johan Boserup og Lise Boserups” Scholarship and the Aase and Ejnar Danielsen’s Foundation.

ID: 64081782