Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Sertoli Cell Number Correlates with Serum Inhibin B in Infant Cryptorchid Boys

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Surgical Management of Undescended Testis - Timetable and Outcome: A Debate

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Building the mammalian testis: origins, differentiation, and assembly of the component cell populations

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Cell populations and molecular biomarkers in blood and urine characterise nephropathy in type 1 diabetes

    Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

  2. Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Comprehensive profiling of proteome changes upon sequential deletion of deubiquitylating enzymes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Sonia Silva
  • Veronika Altmannova
  • Sarah Luke-Glaser
  • Peter Henriksen
  • Irene Gallina
  • Xuejiao Yang
  • Chunaram Choudhary
  • Brian Luke
  • Lumir Krejci
  • Michael Lisby
Vis graf over relationer

Mph1 is a member of the conserved FANCM family of DNA motor proteins that play key roles in genome maintenance processes underlying Fanconi anemia, a cancer predisposition syndrome in humans. Here, we identify Mte1 as a novel interactor of the Mph1 helicase in Saccharomyces cerevisiae. In vitro, Mte1 (Mph1-associated telomere maintenance protein 1) binds directly to DNA with a preference for branched molecules such as D loops and fork structures. In addition, Mte1 stimulates the helicase and fork regression activities of Mph1 while inhibiting the ability of Mph1 to dissociate recombination intermediates. Deletion of MTE1 reduces crossover recombination and suppresses the sensitivity of mph1Δ mutant cells to replication stress. Mph1 and Mte1 interdependently colocalize at DNA damage-induced foci and dysfunctional telomeres, and MTE1 deletion results in elongated telomeres. Taken together, our data indicate that Mte1 plays a role in regulation of crossover recombination, response to replication stress, and telomere maintenance.

OriginalsprogEngelsk
TidsskriftGenes & Development
Vol/bind30
Udgave nummer6
Sider (fra-til)700-17
Antal sider18
ISSN0890-9369
DOI
StatusUdgivet - 15 mar. 2016
Eksternt udgivetJa

ID: 54999837