TY - JOUR
T1 - MSH6 mutations are frequent in hereditary nonpolyposis colorectal cancer families with normal pMSH6 expression as detected by immunohistochemistry
AU - Okkels, Henrik
AU - Lindorff-Larsen, Karen
AU - Thorlasius-Ussing, Ole
AU - Vyberg, Mogens
AU - Lindebjerg, Jan
AU - Sunde, Lone
AU - Bernstein, Inge
AU - Klarskov, Louise
AU - Holck, Susanne
AU - Krarup, Henrik Bygum
PY - 2012
Y1 - 2012
N2 - Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant condition accounting for 2% to 4% of all colorectal cancer cases worldwide. Families with germ line mutations in 1 of 6 mismatch repair genes are known as Lynch syndrome families. The largest number of mutations has been detected in the mismatch repair genes MLH1 and MSH2, but several mutations in MSH6 have also been demonstrated.
AB - Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant condition accounting for 2% to 4% of all colorectal cancer cases worldwide. Families with germ line mutations in 1 of 6 mismatch repair genes are known as Lynch syndrome families. The largest number of mutations has been detected in the mismatch repair genes MLH1 and MSH2, but several mutations in MSH6 have also been demonstrated.
U2 - 10.1097/PAI.0b013e318249739b
DO - 10.1097/PAI.0b013e318249739b
M3 - Journal article
C2 - 22495361
SN - 1541-2016
VL - 20
SP - 470
EP - 477
JO - Applied Immunohistochemistry & Molecular Morphology
JF - Applied Immunohistochemistry & Molecular Morphology
IS - 5
ER -