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MRI in Neuromuscular Diseases: An Emerging Diagnostic Tool and Biomarker for Prognosis and Efficacy

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Vis graf over relationer

There is an unmet need to identify biomarkers sensitive to change in rare, slowly progressive neuromuscular diseases. Quantitative magnetic resonance imaging (MRI) of muscle may offer this opportunity, as it is noninvasive and can be carried out almost independent of patient cooperation and disease severity. Muscle fat content correlates with muscle function in neuromuscular diseases, and changes in fat content precede changes in function, which suggests that muscle MRI is a strong biomarker candidate to predict prognosis and treatment efficacy. In this paper, we review the evidence suggesting that muscle MRI may be an important biomarker for diagnosis and to monitor change in disease severity. ANN NEUROL 2020;88:669-681.

OriginalsprogEngelsk
TidsskriftAnnals of Neurology
Vol/bind88
Udgave nummer4
Sider (fra-til)669-681
Antal sider13
ISSN0364-5134
DOI
StatusUdgivet - okt. 2020

Bibliografisk note

© 2020 American Neurological Association.

ID: 61073243