Mortality, risk factors, and causes of death among people with tuberculosis in Denmark, 1990 - 2018

Anne Christine Nordholm*, Aase Bengaard Andersen, Christian Wejse, Anders Norman, Claus Thorn Ekstrøm, Peter Henrik Andersen, Troels Lillebaek, Anders Koch

*Corresponding author af dette arbejde
1 Citationer (Scopus)

Abstract

OBJECTIVES: This study aimed to analyze mortality, risk factors, and causes of death among people with tuberculosis (TB).

METHODS: This is a population-based cohort study with patients with TB ≥18 years notified from 1990 to 2018 in Denmark, compared with sex- and age-matched controls. Mortality was assessed in Kaplan-Meier models and risk factors for death were estimated in Cox proportional hazards models.

RESULTS: Overall mortality was twofold higher among people with TB compared with controls up to 15 years after TB diagnosis (hazard ratio [HR]: 2.18, 95% confidence interval [CI]: 2.06-2.29, P <0.0001). Danes with TB were three times more likely to die than migrants (adjusted HR: 3.13, 95% CI: 2.84-3.45, P <0.0001). Risk factors for death included living alone, being unemployed, having low income, and comorbidities such as mental illness with substance abuse, lung diseases, hepatitis, and HIV. TB was the most common cause of death (21%), followed by chronic obstructive pulmonary disease (7%), lung cancer (6%), alcoholic liver disease (5%), and mental illness with substance abuse (4%).

CONCLUSION: People with TB had substantially inferior survival up to 15 years after TB diagnosis, in particular, socially disadvantaged Danes with TB with specific comorbidities. This may reflect unmet needs for enhanced treatment of other medical/social conditions during TB treatment.

OriginalsprogEngelsk
TidsskriftInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Vol/bind130
Sider (fra-til)76-82
Antal sider7
ISSN1201-9712
DOI
StatusUdgivet - maj 2023

Fingeraftryk

Dyk ned i forskningsemnerne om 'Mortality, risk factors, and causes of death among people with tuberculosis in Denmark, 1990 - 2018'. Sammen danner de et unikt fingeraftryk.

Citationsformater