Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Mortality in women treated with assisted reproductive technology treatment - addressing the healthy patient effect

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Levels of and Changes in Childhood Body Mass Index in Relation to Risk of Atrial Fibrillation and Atrial Flutter in Adulthood

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Infertility in a Cohort of Male Danish Firefighters: A Register-Based Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Semen Quality as a Predictor of Subsequent Morbidity: A Danish Cohort Study of 4,712 Men With Long-Term Follow-up

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Patients' attitudes and preferences towards a freeze-all strategy in ART treatment

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Night work and sick leave during pregnancy: a national register-based within-worker cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The health of children conceived by ART: 'the chicken or the egg?'

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Magnetic Resonance Imaging: A New Tool to Optimize the Prediction of Fetal Anemia?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Previous studies have reported reduced mortality among women undergoing assisted reproductive technology (ART) treatment, possibly related to selection of healthy women into ART treatment. The aim of this study was to explore the impact of relevant selection factors on the association between ART treatment and mortality and explore effect modification by parity. Women treated with ART in fertility clinics in Denmark during 1994-2009 (n = 42,897) were age-matched with untreated women from the background population (n = 204,514) and followed until ultimo 2010. With adjustment for relevant confounders, the risk of death was lower among ART-treated women immediately after ART treatment (HR = 0.68, 95% CI: 0.63, 0.74), but there was no apparent difference after 10 years (HR = 0.92, 95% CI: 0.79, 1.07). Having children prior to ART treatment was associated with a markedly reduced mortality (HR = 0.45, 95% CI: 0.38, 0.53), possibly due to better health among fertile women. While the frequency of previous medical and psychiatric diagnoses among ART-treated and untreated women was similar, differences in disease severity could explain the reduced mortality among ART-treated women, as poor prognosis would make ART treatment initiation unlikely. The survival advantage among ART-treated women is likely a selection rather than a biological phenomenon.

OriginalsprogEngelsk
TidsskriftAmerican Journal of Epidemiology
Vol/bind187
Udgave nummer9
ISSN0002-9262
DOI
StatusUdgivet - 1 sep. 2018

ID: 54357027