TY - JOUR
T1 - Mortality in patients with Chronic Hepatitis C and cirrhosis compared to the general population - a Danish cohort study
AU - Hallager, Sofie
AU - Brehm Christensen, Peer
AU - Ladelund, Steen
AU - Rye Clausen, Mette
AU - Lund Laursen, Alex
AU - Møller, Axel
AU - Schlichting, Poul
AU - Galmstrup Madsen, Lone
AU - Gerstoft, Jan
AU - Lunding, Suzanne
AU - Elmegaard Grønbæk, Karin
AU - Bygum Krarup, Henrik
AU - Weis, Nina
N1 - © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail [email protected].
PY - 2017/1
Y1 - 2017/1
N2 - BACKGROUND: Knowledge of mortality in patients with Chronic Hepatitis C (CHC) with cirrhosis is limited. This study aimed to estimate all-cause mortality among CHC patients with and without cirrhosis in Denmark compared to the general population.METHODS: Patients registered in The Danish Database for Hepatitis B and C with CHC and a liver fibrosis assessment were eligible for inclusion. Liver fibrosis was based on liver biopsy, transient elastography, and clinical cirrhosis. Up to 20 sex- and age-matched individuals per patient were identified in the general population. Data were extracted from nationwide registries.RESULTS: 3,410 CHC patients (1,014 with cirrhosis), and 67,315 matched individuals were included. Adjusted mortality rate ratios (MRR) between patients with and without cirrhosis and their comparison cohorts were 5.64 [CI95% 4.76; 6.67] and 1.94 [1.55; 2.42], respectively. Cirrhosis among patients was associated with a MRR of 4.03 [3.43; 4.72]. A cure for CHC was associated with a MRR of 0.64 [0.40; 1.01] among cirrhotic patients and 2.33 [1.47; 3.67] compared to the general population.CONCLUSIONS: Mortality was high among CHC patients with and without cirrhosis compared to the general population. Curing CHC was associated with reduced mortality among cirrhotic patients but remained higher than the general population.
AB - BACKGROUND: Knowledge of mortality in patients with Chronic Hepatitis C (CHC) with cirrhosis is limited. This study aimed to estimate all-cause mortality among CHC patients with and without cirrhosis in Denmark compared to the general population.METHODS: Patients registered in The Danish Database for Hepatitis B and C with CHC and a liver fibrosis assessment were eligible for inclusion. Liver fibrosis was based on liver biopsy, transient elastography, and clinical cirrhosis. Up to 20 sex- and age-matched individuals per patient were identified in the general population. Data were extracted from nationwide registries.RESULTS: 3,410 CHC patients (1,014 with cirrhosis), and 67,315 matched individuals were included. Adjusted mortality rate ratios (MRR) between patients with and without cirrhosis and their comparison cohorts were 5.64 [CI95% 4.76; 6.67] and 1.94 [1.55; 2.42], respectively. Cirrhosis among patients was associated with a MRR of 4.03 [3.43; 4.72]. A cure for CHC was associated with a MRR of 0.64 [0.40; 1.01] among cirrhotic patients and 2.33 [1.47; 3.67] compared to the general population.CONCLUSIONS: Mortality was high among CHC patients with and without cirrhosis compared to the general population. Curing CHC was associated with reduced mortality among cirrhotic patients but remained higher than the general population.
U2 - 10.1093/infdis/jiw527
DO - 10.1093/infdis/jiw527
M3 - Journal article
C2 - 27803168
SN - 0022-1899
VL - 215
SP - 192
EP - 201
JO - The Journal of infectious diseases
JF - The Journal of infectious diseases
IS - 2
ER -