TY - JOUR
T1 - Mortality in children, adolescents, and adults with attention deficit hyperactivity disorder
T2 - a nationwide cohort study
AU - Dalsgaard, Søren
AU - Østergaard, Søren Dinesen
AU - Leckman, James F
AU - Mortensen, Preben Bo
AU - Pedersen, Marianne Giørtz
N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.
PY - 2015/3/30
Y1 - 2015/3/30
N2 - BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is a common mental disorder associated with factors that are likely to increase mortality, such as oppositional defiant disorder or conduct disorder, criminality, accidents, and substance misuse. However, whether ADHD itself is associated with increased mortality remains unknown. We aimed to assess ADHD-related mortality in a large cohort of Danish individuals.METHODS: By use of the Danish national registers, we followed up 1·92 million individuals, including 32 061 with ADHD, from their first birthday through to 2013. We estimated mortality rate ratios (MRRs), adjusted for calendar year, age, sex, family history of psychiatric disorders, maternal and paternal age, and parental educational and employment status, by Poisson regression, to compare individuals with and without ADHD.FINDINGS: During follow-up (24·9 million person-years), 5580 cohort members died. The mortality rate per 10 000 person-years was 5·85 among individuals with ADHD compared with 2·21 in those without (corresponding to a fully adjusted MRR of 2·07, 95% CI 1·70-2·50; p
AB - BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is a common mental disorder associated with factors that are likely to increase mortality, such as oppositional defiant disorder or conduct disorder, criminality, accidents, and substance misuse. However, whether ADHD itself is associated with increased mortality remains unknown. We aimed to assess ADHD-related mortality in a large cohort of Danish individuals.METHODS: By use of the Danish national registers, we followed up 1·92 million individuals, including 32 061 with ADHD, from their first birthday through to 2013. We estimated mortality rate ratios (MRRs), adjusted for calendar year, age, sex, family history of psychiatric disorders, maternal and paternal age, and parental educational and employment status, by Poisson regression, to compare individuals with and without ADHD.FINDINGS: During follow-up (24·9 million person-years), 5580 cohort members died. The mortality rate per 10 000 person-years was 5·85 among individuals with ADHD compared with 2·21 in those without (corresponding to a fully adjusted MRR of 2·07, 95% CI 1·70-2·50; p
U2 - 10.1016/S0140-6736(14)61684-6
DO - 10.1016/S0140-6736(14)61684-6
M3 - Journal article
SN - 0140-6736
VL - 385
SP - 2190
EP - 2196
JO - Lancet
JF - Lancet
IS - 9983
ER -