Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Mortality and major complications after emergency laparotomy: A pilot study of risk prediction model development by preoperative blood-based immune parameters

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. A marking of the cricothyroid membrane with extended neck returns to correct position after neck manipulation and repositioning

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Association between transfusion of blood products and acute kidney injury following cardiac surgery

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Hypoxemia following hospital discharge after fast-track hip- and knee arthroplasty-a prospective observational study subanalysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Ketamine for rapid sequence intubation in adult trauma patients: A retrospective observational study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Soluble Urokinase Receptor (SuPAR) in COVID-19-Related AKI

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Automatic oxygen titration with O2matic® to patients admitted with COVID-19 and hypoxemic respiratory failure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Preoperative high-dose Steroids in Total Knee and Hip Arthroplasty - Protocols for three randomized controlled trials

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Emergency laparotomy success - optimisation or triage?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Emergency laparotomy is associated with high risk of postoperative complications and mortality. Preoperative identification of patients at high risk of adverse outcome is important. The immune response to conditions requiring emergency laparotomy is not understood in detail. The present study describes preoperative blood-based immune profiles and their potential value in surgical risk assessment.

METHOD: Patients (N=100) referred for emergency laparotomy at Hvidovre Hospital were consecutively included from 3 June 2013 - 11 April 2014. All patients had blood samples collected before surgery and the immune parameters c-reactive protein (CRP), Interleukin-6 (IL-6), Interleukin-10 (IL-10), interferon-γ induced protein 10 kDa (IP-10), Tumor Necrosis Factor α (TNF-α) and soluble urokinase plasminogen receptor activator (suPAR) were determined. Patients were stratified according to major postoperative complications (including death), 30- and 180-day mortality. Using logistic regression models and receiver operating characteristics curves the predictive ability of the immune parameters were estimated.

RESULTS: Major complications were recorded in 45 (45.0%) of the patients, whereas 30-day and 180-day mortalities were 17 (17.0%) and 25 (25.0%), respectively. Concentrations of suPAR and TNF-α were associated with major complications while CRP, IL-6, suPAR and TNF-α were associated with mortality. Adding the combined immune parameters to a regression model including age, sex, American Society of Anesthesiologists physical status and Eastern Cooperative Oncology Group Performance Status significantly improved the predictive ability for major complications, 30-day mortality and 180-day mortality.

CONCLUSION: In emergency laparotomy, preoperative blood-based immune parameters added predictive power to regression models and could be considered in risk prediction model development.

OriginalsprogEngelsk
TidsskriftActa Anaesthesiologica Scandinavica
ISSN0001-5172
DOI
StatusE-pub ahead of print - 27 okt. 2020

Bibliografisk note

This article is protected by copyright. All rights reserved.

ID: 61112931