Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Mortality and GH deficiency: a nationwide study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Distinguishing between hidden testes and anorchia: The role of endocrine evaluation in infancy and childhood

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Heritability of pubertal timing: detailed evaluation of specific milestones in healthy boys and girls

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Hashimoto's thyroiditis as a risk factor for thyroid cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Disease Control and Gender Predict the Socioeconomic Effects of Acromegaly: A Nationwide Cohort Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Ecological momentary assessments (EMAs) did not improve responsiveness of patient-reported outcomes on quality of life

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Is the alpha-galactosidase A variant p.Asp313Tyr (p.D313Y) pathogenic for Fabry disease? A systematic review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

OBJECTIVE: To estimate the mortality in Denmark in patients suffering from GH deficiency (GHD).

DESIGN: Mortality was analyzed in 1794 GHD patients and 8014 controls matched on age and gender. All records in GHD patients were studied and additional morbidity noted. Patients were divided into childhood onset (CO) and adult onset (AO), discriminated by an age cutoff below or above 18 years at onset of GHD.

METHOD: Data on death were identified in national registries. Sex- and cause-specific mortalities were identified in CO and AO GHD when compared with controls.

RESULTS: Mortality was increased in CO and AO GHD in both genders, when compared with controls. The hazard ratio (HR) for CO males was 8.3 (95% confidence interval (CI) 4.5-15.1) and for females 9.4 (CI 4.6-19.4). For AO males, HR was 1.9 (CI 1.7-2.2) and for females 3.4 (CI 2.9-4.0). We found a significantly higher HR in AO females versus AO males, both compared with controls (P < 0.001). In AO, mortality was increased due to cancer in all subgroups, due to circulatory diseases in all age groups for females and for males in the oldest age group. For CO, the increased mortality was due to cancer.

CONCLUSIONS: We found a significantly increased mortality in GHD patients when compared with controls, possibly due to their hypopituitary status. Mortality was increased in AO female patients when compared with males. For CO and AO GHD, different causes of significantly increased mortality were identified.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Endocrinology
Vol/bind157
Udgave nummer1
Sider (fra-til)9-18
Antal sider10
ISSN0804-4643
DOI
StatusUdgivet - jul. 2007

ID: 59038756