Monoklonal gammopati med ubestemt signifikans

Niels Emil Ulrich Hermansen; Trine Silkjær; Charlotte Toftmann Hansen; Thomas Granum Aagaard; Henrik Gregersen

Monoklonal gammopati med ubestemt signifikans

Niels Emil Ulrich Hermansen, Trine Silkjær, Charlotte Toftmann Hansen, Thomas Granum Aagaard, Henrik Gregersen

Abstract

This review summarises the work-up of patients with monoclonal gammopathy of undetermined significance (MGUS). In persons above 70 years of age, around 5% have MGUS, a premalignant state with a monoclonal plasma immunoglobulin or light chain (M protein) in blood and/or urine. Continuous follow-up is recommended due to a risk of malignant progression of around 1% per year. Immunoglobulin M MGUS primarily progresses to Waldenström's macroglobulinaemia, whereas non-immunoglobulin M MGUS typically progresses to multiple myeloma or amyloid light-chain amyloidosis. Treatment is unnecessary unless in rare cases of severe non-malignant complications. Screening is not advised.

Bidragets oversatte titel	Monoclonal gammopathy of undetermined significance
Originalsprog	Dansk
Artikelnummer	V08190428
Tidsskrift	Ugeskrift for Laeger
Vol/bind	182
Udgave nummer	10
Antal sider	5
ISSN	0041-5782
Status	Udgivet - 2 mar. 2020
Udgivet eksternt	Ja

Emneord

Humans
Immunoglobulin Light-chain Amyloidosis
Monoclonal Gammopathy of Undetermined Significance/diagnosis
Multiple Myeloma
Waldenstrom Macroglobulinemia/diagnosis

Citationsformater

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title = "Monoklonal gammopati med ubestemt signifikans",

abstract = "This review summarises the work-up of patients with monoclonal gammopathy of undetermined significance (MGUS). In persons above 70 years of age, around 5% have MGUS, a premalignant state with a monoclonal plasma immunoglobulin or light chain (M protein) in blood and/or urine. Continuous follow-up is recommended due to a risk of malignant progression of around 1% per year. Immunoglobulin M MGUS primarily progresses to Waldenstr{\"o}m's macroglobulinaemia, whereas non-immunoglobulin M MGUS typically progresses to multiple myeloma or amyloid light-chain amyloidosis. Treatment is unnecessary unless in rare cases of severe non-malignant complications. Screening is not advised.",

keywords = "Humans, Immunoglobulin Light-chain Amyloidosis, Monoclonal Gammopathy of Undetermined Significance/diagnosis, Multiple Myeloma, Waldenstrom Macroglobulinemia/diagnosis",

author = "Hermansen, {Niels Emil Ulrich} and Trine Silkj{\ae}r and Hansen, {Charlotte Toftmann} and Aagaard, {Thomas Granum} and Henrik Gregersen",

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day = "2",

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TY - JOUR

T1 - Monoklonal gammopati med ubestemt signifikans

AU - Hermansen, Niels Emil Ulrich

AU - Silkjær, Trine

AU - Hansen, Charlotte Toftmann

AU - Aagaard, Thomas Granum

AU - Gregersen, Henrik

PY - 2020/3/2

Y1 - 2020/3/2

N2 - This review summarises the work-up of patients with monoclonal gammopathy of undetermined significance (MGUS). In persons above 70 years of age, around 5% have MGUS, a premalignant state with a monoclonal plasma immunoglobulin or light chain (M protein) in blood and/or urine. Continuous follow-up is recommended due to a risk of malignant progression of around 1% per year. Immunoglobulin M MGUS primarily progresses to Waldenström's macroglobulinaemia, whereas non-immunoglobulin M MGUS typically progresses to multiple myeloma or amyloid light-chain amyloidosis. Treatment is unnecessary unless in rare cases of severe non-malignant complications. Screening is not advised.

AB - This review summarises the work-up of patients with monoclonal gammopathy of undetermined significance (MGUS). In persons above 70 years of age, around 5% have MGUS, a premalignant state with a monoclonal plasma immunoglobulin or light chain (M protein) in blood and/or urine. Continuous follow-up is recommended due to a risk of malignant progression of around 1% per year. Immunoglobulin M MGUS primarily progresses to Waldenström's macroglobulinaemia, whereas non-immunoglobulin M MGUS typically progresses to multiple myeloma or amyloid light-chain amyloidosis. Treatment is unnecessary unless in rare cases of severe non-malignant complications. Screening is not advised.

KW - Humans

KW - Immunoglobulin Light-chain Amyloidosis

KW - Monoclonal Gammopathy of Undetermined Significance/diagnosis

KW - Multiple Myeloma

KW - Waldenstrom Macroglobulinemia/diagnosis

M3 - Review

C2 - 32138824

SN - 0041-5782

VL - 182

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 10

M1 - V08190428

ER -

Monoklonal gammopati med ubestemt signifikans

Abstract

Emneord

Fingeraftryk

Citationsformater