Monitorering af tumornekrosefaktor alfa-haemmeres biotilgaengelighed, farmakokinetik og immunogenicitet

Casper Steenholdt; Mark Ainsworth; Ole Østergaard Thomsen; Jørn Brynskov; Klaus Bendtzen

Monitorering af tumornekrosefaktor alfa-haemmeres biotilgaengelighed, farmakokinetik og immunogenicitet

Casper Steenholdt, Mark Ainsworth, Ole Østergaard Thomsen, Jørn Brynskov, Klaus Bendtzen

Mave-, Tarm- og Leversygdomme

2 Citationer (Scopus)

Abstract

Treatment of inflammatory bowel disease (IBD) with antibodies against tumour necrosis factor-alpha (TNF) is effective. Not all patients respond, however, and the effect wears off in a considerable fraction of initial responders over time. Individual differences in bioavailability, pharmacokinetics and immunogenicity are now recognized as essential problems in the use of biologicals, and blood measurements of functional anti-TNF antibodies and antibodies against anti-TNF drugs with robust and clinically relevant methods may optimize treatment of IBD through individualized therapeutic regimens.

Bidragets oversatte titel	[Monitoring of bioavailability, pharmacokinetics and immunogenicity of tumour necrosis factor-alpha inhibitors]
Originalsprog	Dansk
Tidsskrift	Ugeskrift for Laeger
Vol/bind	172
Udgave nummer	1
Sider (fra-til)	44-7
Antal sider	4
Status	Udgivet - 4 jan. 2010

Citationsformater

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abstract = "Treatment of inflammatory bowel disease (IBD) with antibodies against tumour necrosis factor-alpha (TNF) is effective. Not all patients respond, however, and the effect wears off in a considerable fraction of initial responders over time. Individual differences in bioavailability, pharmacokinetics and immunogenicity are now recognized as essential problems in the use of biologicals, and blood measurements of functional anti-TNF antibodies and antibodies against anti-TNF drugs with robust and clinically relevant methods may optimize treatment of IBD through individualized therapeutic regimens.",

author = "Casper Steenholdt and Mark Ainsworth and Thomsen, {Ole {\O}stergaard} and J{\o}rn Brynskov and Klaus Bendtzen",

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language = "Dansk",

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AU - Steenholdt, Casper

AU - Ainsworth, Mark

AU - Thomsen, Ole Østergaard

AU - Brynskov, Jørn

AU - Bendtzen, Klaus

PY - 2010/1/4

Y1 - 2010/1/4

N2 - Treatment of inflammatory bowel disease (IBD) with antibodies against tumour necrosis factor-alpha (TNF) is effective. Not all patients respond, however, and the effect wears off in a considerable fraction of initial responders over time. Individual differences in bioavailability, pharmacokinetics and immunogenicity are now recognized as essential problems in the use of biologicals, and blood measurements of functional anti-TNF antibodies and antibodies against anti-TNF drugs with robust and clinically relevant methods may optimize treatment of IBD through individualized therapeutic regimens.

AB - Treatment of inflammatory bowel disease (IBD) with antibodies against tumour necrosis factor-alpha (TNF) is effective. Not all patients respond, however, and the effect wears off in a considerable fraction of initial responders over time. Individual differences in bioavailability, pharmacokinetics and immunogenicity are now recognized as essential problems in the use of biologicals, and blood measurements of functional anti-TNF antibodies and antibodies against anti-TNF drugs with robust and clinically relevant methods may optimize treatment of IBD through individualized therapeutic regimens.

M3 - Tidsskriftartikel

C2 - 20056095

SN - 1399-4174

VL - 172

SP - 44

EP - 47

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 1

ER -

Monitorering af tumornekrosefaktor alfa-haemmeres biotilgaengelighed, farmakokinetik og immunogenicitet

Abstract

Fingeraftryk

Citationsformater