Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Molecular indicators of denervation in aging human skeletal muscle

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Metastatic melanoma presenting with subacute sensory neuronopathy

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  2. Quantitative electromyography: Normative data in paraspinal muscles

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Conference report on contractures in musculoskeletal and neurological conditions

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Moderate-intensity aerobic exercise improves physical fitness in bethlem myopathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Long-term safety and efficacy of eculizumab in generalized myasthenia gravis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Collagens in primary frozen shoulder: expression of collagen mRNA isoforms in the different phases of the disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Distribution of concurrent training sessions does not impact endurance adaptation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. UTE T2* mapping of tendinopathic patellar tendons: an MRI reproducibility study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

INTRODUCTION: Muscle fiber denervation increases with age, yet studies at the tissue level are sparse due to the challenging nature of establishing the relative role of regeneration and denervation.

METHODS: Muscle biopsies were obtained from the vastus lateralis of 70 healthy men (aged 72 ± 6 years; range, 65-94). Messenger RNA (mRNA) levels of acetylcholine receptors (AchR) were measured, and sections were stained for embryonic myosin, neonatal myosin (MHCn ), and neural cell adhesion molecule (NCAM).

RESULTS: Embryonic myosin+ fibers were rare, while MHCn+ and NCAM+ fibers were observed in all samples. Age (range, 65-94 years) was negatively associated with AchRγ mRNA.

DISCUSSION: Muscle from healthy older individuals expressed developmental myosins to varying degrees but more than has been previously reported for young individuals. Along with the AchR correlations, we propose that these findings support the presence of neuromuscular junction destabilization, denervation, and reinnervation in aging human skeletal muscle.

OriginalsprogEngelsk
TidsskriftMuscle & Nerve
Vol/bind60
Udgave nummer4
Sider (fra-til)453-463
Antal sider11
ISSN0148-639X
DOI
StatusUdgivet - okt. 2019

ID: 59363026