@article{6f30e439eb0c48d58177d8146899fec3,
title = "Molecular evolution of GB virus B hepatitis virus during acute resolving and persistent infections in experimentally infected tamarins",
abstract = "GB virus B (GBV-B) causes acute hepatitis in experimentally infected tamarins. We compared evolutionary features in acute resolving and persistent GBV-B infection. We detected no evidence of evolution in four animals with clearance during weeks 9-12, whereas three animals with clearance during weeks 13-26 had several substitutions in their polyprotein sequence. A single tamarin had long-term GBV-B viraemia; analysis of virus recovered at weeks 2, 5, 12, 20, 26, 52 and 104 demonstrated that mutations accumulated over time. Overall, the amino acid substitution rate was 3.5x10(-3) and 1.1x10(-3) substitutions per site year(-1) during weeks 1-52 and 53-104, respectively. Thus, there was a significant decrease in evolution over time, as found for hepatitis C virus. The rate of non-synonymous substitution per non-synonymous site compared with that of synonymous substitution per synonymous site decreased over time, suggesting reduction of positive selective pressure. These data demonstrate that prolonged GBV-B infection is associated with viral evolution.",
keywords = "Amino Acid Substitution, Animals, Disease Models, Animal, Evolution, Molecular, GB virus B, Gene Products, pol, Hepatitis, Viral, Animal, Leontopithecus, Monkey Diseases",
author = "Shingo Takikawa and Engle, {Ronald E} and Faulk, {Kristina N} and Emerson, {Suzanne U} and Purcell, {Robert H} and Jens Bukh",
year = "2010",
doi = "10.1099/vir.0.015750-0",
language = "English",
volume = "91",
pages = "727--33",
journal = "The Journal of general virology",
issn = "1465-2099",
publisher = "Microbiology Society",
number = "Pt 3",
}